Memorial Sloan Kettering Cancer Center Data Scientist
Interview Questions & Guide 2026

• Solve six prompts spanning aggregation, joins, window functions and date arithmetic in 60 minutes total, stopping at 10 minutes each whether or not it works, and mark every prompt as solved, solved slowly, or stuck.
• For each unsolved prompt write the single blocking sentence (I lost the grain, I did not know the frame clause, I could not express the date boundary) instead of reading the solution.
• Translate one pandas transformation you know well into SQL and one SQL query into pandas, checking that both return the same row count and the same totals.

Deliverable: A scored six-row table, one line per prompt, saved for the day-seven re-run.

• Answer ten short questions in writing with nothing open: what a p-value is conditional on, what a 95 percent interval covers across repeated samples, when a paired test is the right one, what the bootstrap estimates, why multiple comparisons inflate false positives, how controlling the family-wise error rate differs from controlling the false discovery rate, what power depends on, what a missed real effect costs a product, the three situations where the central limit theorem does not rescue you (small n, very heavy tails, dependent observations), and what a standard error is the standard deviation of.
• Grade yourself against a reference and count only the answers that were exactly right, not the ones that were nearly right.
• Rewrite the two weakest answers the following morning from memory in full sentences.

Deliverable: Ten graded answers with an honest count of exact hits.

• Take one tabular dataset end to end in 90 minutes: a leakage-safe split, a baseline that is not a model (majority class or historical mean), one regularized linear model, one gradient-boosted tree, and a single evaluation metric chosen before you look at any result.
• Write why that metric fits the cost structure: precision at a fixed recall for alerting, calibration for anything feeding a price or a threshold, ranking metrics for retrieval, and note that area under the ROC curve is insensitive to class balance in a way that can flatter a rare-positive problem.
• Name the leak you were most likely to introduce (an encoding fit on all rows before splitting, or a feature computed after the label's timestamp) and write the check that would have caught it.

Deliverable: A notebook whose first cell states the metric and the baseline, plus two lines on what beat what and by how much.

• Answer three case prompts aloud at 15 minutes each, timing how long passes before you state a success metric.
• For one case write the first segmentation you would run and the row counts you expect per segment, so that a tiny segment cannot quietly drive the conclusion.
• Take a metric definition you did not write, from a public dashboard, a textbook, or documentation you already have open, and list every place two analysts implementing it would diverge: which rows the denominator admits, whether the unit is an account or a person, what the time window is anchored to, and what happens to data that arrives late. Then write the one question that would close the largest of those gaps.

Deliverable: Three recorded case answers plus an ambiguity list for a metric someone else defined, ending in the single question you would ask about it.

• Rank the four areas by how many bullet points in the role description each one covers, pick the top one, and spend the entire day inside it.
• Work the six hardest problems you can find in that area and for each write the generalizable move you should have reached for first, rather than the answer.
• Re-solve the two you failed the same evening with notes closed.

Deliverable: Six generalizable moves written as instructions to yourself, not as solutions.

• Repeat the depth protocol on the second-ranked area with the same six-problem structure.
• Construct one problem that requires both areas at once, for example a metric redefinition whose effect you must validate with a test whose readout you then have to query.
• Solve your own combined problem end to end and note where the handoff between the two areas cost you time.

Deliverable: One combined problem, solved end to end, with the handoff failure written down.

• Re-run the six prompts from day one under the same clock and compare both correctness and time.
• Run a 60-minute mixed mock that moves between areas without warning, since switching cost is what breadth passes do not train.
• Write the two areas you would still fail on, and the sentence you will use in the interview when you hit one of them.

Deliverable: A before-and-after score table plus a written plan for the two remaining gaps.