As a Machine Learning Engineer at MSD, you occupy a critical intersection between advanced data science and scalable software engineering. Your work directly impacts the company’s ability to leverage complex datasets to drive innovation in healthcare and pharmaceutical operations. You are not just building models in a vacuum; you are designing robust, production-ready systems that translate machine learning research into tangible business outcomes.
This role requires a unique blend of technical rigor and pragmatic problem-solving. You will contribute to projects involving computer vision, predictive modeling, and automated data pipelines, ensuring that the solutions you build are both performant and maintainable. Success in this position at MSD means you are comfortable navigating ambiguity, collaborating with cross-functional teams, and maintaining a high standard for code quality and algorithmic efficiency.
Preparation focus
editorialNo round sequence has been reported for this company, so work the categories below and confirm the format with your recruiter.
What to demonstrate
- Breadth across SQL, experimentation and product reasoning
- Ability to state assumptions before choosing a method
How to prepare
- Drill the practice exercises below and time yourself
- Prepare three quantified stories about decisions you drove
PracHub editorial advice for the preparation topics above.
Choosing an index from the columns a query mentions rather than from how it filters and orders
A composite B-tree index on (a, b, c) can be seeked only as a left prefix: equality on a, then equality on b, then a range or an ordering on c. A query that filters on b alone cannot seek into it at all and at best gets a full scan of the index; a query that filters a and ranges on b gets no benefit from c, because the index is only sorted by c within a fixed (a, b) pair. The practical consequence is that one index per column is close to useless for multi-predicate queries while a single correctly ordered composite index turns a scan into a lookup. The ordering half is what gets missed: if the index cannot satisfy the ORDER BY, the database must read every matching row and sort before the limit can apply, so a LIMIT 20 over a million matching rows still reads a million rows.
Shipping a migration and the code that depends on it as a single change
During any rolling deploy, and for as long as a rollback remains possible, old and new code execute against the same schema at the same time. A migration that drops or renames a column breaks every instance that has not restarted yet, and code that requires a column the migration has not applied breaks every instance that restarted early. The discipline is expand then contract: add the new column nullable, write both shapes, backfill in batches, move reads across once the backfill is verified, and only then stop writing the old shape and drop it - four deploys, usually spread over days. It feels disproportionate until the first rollback, at which point it is the only reason the previous version still runs.
A queue or buffer with no bound
Every producer-consumer boundary needs a capacity and a policy for reaching it: block the producer, shed load, or drop the oldest entry. Unbounded buffering converts a temporary slowdown into memory exhaustion and hides the backpressure signal that would have revealed the consumer was falling behind.
Never running a concrete value through the code
Trace one small input and one edge input by hand, index by index, out loud. Re-reading your own code catches design mistakes; walking a real value through it catches the off-by-one, the uninitialised accumulator and the loop that never advances.
Choose a category, try a prompt, then open its approach, worked solution or follow-up when you need it.
Can you walk us through your most recent machine learning project and …
Can you walk us through your most recent machine learning project and the specific trade-offs you made?
Approach
- Pick the metric from the cost of each error type, not from habit.
- Say how you would validate it, and where leakage could enter the split.
- State the learning problem: the label, the unit of prediction and how the model is used.
Follow-up
- How would you know the model is overfitting?
- Where could label leakage enter this setup?
Explain the difference between various loss functions and how they inf…
Explain the difference between various loss functions and how they influence model convergence.
Approach
- Say how you would validate it, and where leakage could enter the split.
- Name the simplest model that could work and what would make you move past it.
- Pick the metric from the cost of each error type, not from habit.
Follow-up
- Where could label leakage enter this setup?
- What changes if the classes are heavily imbalanced?
Merge partitioned event streams into one ordered feed with bounded lateness
The read-model service consumes 64 log partitions carrying about 4,000 events per second in total. Each partition is ordered within itself, but partitions drift by up to 30 seconds, and the activity feed must present a tenant's events in occurred_at order. Produce the merge. State its complexity, the buffer it requires in events and in bytes, what happens when one partition is idle, and what you do with an event that arrives after you have already emitted its position. Payloads average 1 KB.
Approach
- Merge with a min-heap over the 64 partition heads keyed on (occurred_at, event_id): O(log P) per event and O(n log P) overall. The tie-break on event_id is what makes the output deterministic when two partitions carry the same millisecond, which matters because the feed is paginated and a non-deterministic order reorders pages under the reader.
- Emitting the heap head is only correct once every partition has produced everything up to that timestamp, so the emit condition is a watermark: the minimum across partitions of the highest occurred_at seen, less the allowed lateness. Events are held until the watermark passes them, which is what turns individually ordered streams into a jointly ordered one.
- Size the buffer from the lateness rather than guessing: 4,000 events per second times 30 seconds is 120,000 buffered events, and at 1 KB each about 120 MB of heap. That number is the real price of the ordering guarantee and belongs in front of whoever asked for it.
- Handle the idle partition explicitly, because it fails the feed rather than corrupting it: a partition with no traffic never advances its own maximum, so the watermark freezes and output stops entirely. Either every partition emits a periodic idle marker carrying the broker's current time, or the watermark falls back to wall clock for a partition silent beyond a threshold.
- Choose the late-event policy from what the projection is keyed on. The projection upserts on (aggregate_id, aggregate_version) and discards a version it has already applied, so a late event is safe to apply out of order and correctness never depended on the merge at all. Apply it, recompute the affected feed page, and count lateness so the 30-second budget can be re-derived from data rather than folklore.
- Say what the merge does not buy: ordering is guaranteed within one aggregate by the log's partitioning, and no watermark makes the cross-aggregate order authoritative. Two events from different aggregates in the same millisecond have no true order, so the feed's order is a presentation choice that must be stable rather than correct.
Worked solution 35 min
- Write the heap comparator on (occurred_at, event_id) and the per-partition head refill.
- Write the watermark computation and the emit-loop condition, then list which buffered events are held at a chosen instant.
- Compute the buffer at 4,000 events per second, 30 seconds and 1 KB per event, and state what fraction of a worker's heap that represents.
- Add the idle-partition marker and trace the watermark with one silent partition, both with and without the marker.
- Write the late-event path and name the key that makes applying it safe.
Follow-up
- The lateness budget is raised to five minutes. What is the new buffer, and what besides memory changes?
- The consumer restarts. Where does it resume from, and what does the feed look like for the first 30 seconds?
- One partition is ten minutes behind because its producer is slow. Do you stall the feed or emit without it?
Explain why the owner filter ignores the listing index
The only index on resource is (tenant_id, status, updated_at DESC, resource_id DESC). A new endpoint returns one user's resources across all statuses, newest created first: WHERE tenant_id = $1 AND owner_user_id = $2 ORDER BY created_at DESC LIMIT 20. On a tenant with 2M rows it takes 900 ms and EXPLAIN shows a sort above a large scan. Explain precisely why the existing index cannot serve it, give the index that can, and state which of these the new index still will not help: owner_user_id alone across tenants; the same query ordered by updated_at. PostgreSQL 16.
Approach
- Separate the two jobs an index does. For filtering, a composite btree is seekable only on a left prefix, so with no predicate on status the scan can at best range over tenant_id and test owner_user_id per row; PostgreSQL 16 has no btree skip scan to jump the unconstrained column.
- For ordering, the index is sorted by (status, updated_at) within a tenant and not by created_at, so the LIMIT cannot stop early: every matching row is read and then sorted. That is the 'Sort Method: top-N heapsort' line, and it is why the plan reads 2M rows to answer with 20.
- Derive the replacement from the access path — equality, equality, then the ordering column: CREATE INDEX CONCURRENTLY ON resource (tenant_id, owner_user_id, created_at DESC). The scan seeks to the (tenant, owner) range and walks 20 entries in order, so the Sort node disappears along with the row-read.
- Treat INCLUDE (title, status) as conditional, not free. An index-only scan still visits the heap for any row whose page is not marked all-visible, so on a table taking 1.2k writes/second the win depends on autovacuum keeping the visibility map current, and the wider index costs more on every insert.
- Answer the two negatives explicitly. owner_user_id alone is not a left prefix of the new index, so it degrades to a full scan of the index at best. Ordered by updated_at, the query still seeks on the (tenant, owner) pair but must sort, because only created_at is ordered within that pair.
- Measure both sides with EXPLAIN (ANALYZE, BUFFERS) and compare estimated against actual rows at the lowest node — a 2M-versus-200 misestimate there is usually what chose the plan, and adding an index will not fix a statistics problem.
Worked solution 25 min
- Load 2M resource rows across 5k owners in one tenant, run the query under EXPLAIN (ANALYZE, BUFFERS), and record the node reading the most rows plus the Sort Method line.
- Create (tenant_id, owner_user_id, created_at DESC) concurrently and re-run, confirming the Sort node is gone and actual rows fall to about 20.
- Run the two negative cases and capture the plan for each.
- Re-run the original tenant listing query to confirm the new index has not displaced the index that query depends on.
Follow-up
- 90% of rows are status='active'. Would a partial index WHERE status = 'active' change your answer, and for which of the three queries?
- A dashboard runs this for 40 owners in one page load. What changes about the design?
- How do you roll this index out on a table taking 1.2k writes/second, and what does it cost on every insert from then on?
Stop tag and share joins from fanning out a page
resource_tag is (resource_id, tag_id) with PK (resource_id, tag_id); resource_share is (resource_id, shared_with_user_id, permission). The tagged-and-shared listing inner-joins resource to both, filters tenant_id, tag_id = ANY($2) and shared_with_user_id = $3, orders by updated_at DESC and takes 50. Pages come back with fewer than 50 distinct resources and the total in the header is far too high. Explain the row multiplication, rewrite both the page query and the count query so each is correct, and name the index each one needs. PostgreSQL 16.
Approach
- Do the arithmetic against the predicates that are actually there. An inner join emits one row per matching child row, and both joins are filtered: tag_id = ANY($2) admits only the requested tags, shared_with_user_id = $3 admits one user's share rows. So a resource holding three of the requested tags and shared with $3 once yields three rows, not one — the multiplier is its count of matching tags times its share rows for that single user, and that second factor is 1 unless the table admits duplicate (resource_id, shared_with_user_id) pairs. LIMIT 50 then limits rows rather than resources, and COUNT(*) counts pairs — the header is the product, not the population.
- Reject DISTINCT as the fix. It deduplicates after the product has been built, so the planner must materialise and sort the fanned-out set before the LIMIT can apply, and it leaves any SUM or AVG in the same select list wrong.
- Rewrite both filters as semi-joins, keeping resource as the only row source: AND EXISTS (SELECT 1 FROM resource_tag rt WHERE rt.resource_id = r.resource_id AND rt.tag_id = ANY($2)) and the same shape against resource_share. A semi-join stops at the first match per resource and preserves the driving index order, so ORDER BY updated_at DESC, resource_id DESC LIMIT 50 still stops after 50 rows.
- Count with the same predicates and no join at all: SELECT count(*) FROM resource r WHERE r.tenant_id = $1 AND r.status = 'active' AND EXISTS (...) AND EXISTS (...). Nothing multiplies a resource, so the number is the population.
- Attach the tags for display after the page has been cut — LEFT JOIN LATERAL (SELECT array_agg(rt.tag_id) FROM resource_tag rt WHERE rt.resource_id = p.resource_id) ON TRUE over the 50 returned rows. Aggregate over the page, never over the tenant.
- Index both directions and say which query each serves: PK (resource_id, tag_id) serves the lateral lookup, (tag_id, resource_id) serves the EXISTS probe by tag, and resource_share needs (shared_with_user_id, resource_id) for the same reason. An index covering one direction only leaves the other as a scan.
Follow-up
- The filter changes from 'any of these tags' to 'all of these tags'. Rewrite it and state what it costs relative to the ANY form.
- A resource can be shared with the same user twice under different permissions. Does your count change, and should it?
- Where does the correct total come from when the tenant holds 4M resources and the header must not cost 200 ms?
What are the common challenges you face when deploying machine learnin…
What are the common challenges you face when deploying machine learning models in a production environment?
Approach
- Name what you would monitor after launch and what triggers a retrain.
- Fix the product goal and the online metric before choosing any model.
- Say where features come from at serving time and how they match training.
Follow-up
- What happens when a feature is missing at serving time?
- How would you detect drift before the metric drops?
How do you approach the selection of an architecture for an object det…
How do you approach the selection of an architecture for an object detection task?
Approach
- Name the read and write paths separately; they rarely have the same bottleneck.
- State the consistency you need, and where you are willing to be stale.
- Fix the scope first: who calls this, how often, and what they do when it fails.
Follow-up
- What breaks first when traffic grows ten times?
- How does this behave when that dependency is down for an hour?
Convert the listing endpoint from offset pages to stable cursors
GET /v1/resources returns a tenant's resources newest-updated first, today with page and per_page, backed by index (tenant_id, status, updated_at DESC, resource_id DESC). Callers are a browser feed and a nightly sync job that walks every page. Users report items appearing twice or vanishing between pages, and page 400 is slow. Design the cursor contract: what the cursor contains and how it is encoded, the exact WHERE and ORDER BY, what happens when a row's updated_at changes mid-walk, how a client detects the end, and what the sync job does when a cursor is rejected.
Approach
- Separate the two defects, because they have different fixes. Cost: OFFSET n makes the engine produce and discard n rows, so price grows with page depth rather than page size and page 400 pays for 400 pages of work. Correctness: while the set shifts, rows cross the offset boundary and are skipped or repeated, and nothing in the response lets the client detect it.
- Write the seek: WHERE tenant_id = $1 AND status = $2 AND (updated_at, resource_id) < ($k, $id) ORDER BY updated_at DESC, resource_id DESC LIMIT n. The tie-break is not decoration - updated_at is not unique, and two rows sharing a timestamp across a page boundary reintroduce exactly the skip this was adopted to remove. PostgreSQL seeks the composite index on the row-value comparison directly; on an engine that does not optimise a row constructor, expand it into the equivalent OR form or the plan quietly degrades to a scan.
- Encode the cursor as an opaque token carrying the sort key, the id, and a fingerprint of the filter and sort order, signed or at minimum validated. A cursor replayed against a different sort or filter must be a 400 with its own code, not a silently wrong page - the sync job cannot notice the difference otherwise.
- State the guarantee precisely rather than generously. Keyset is stable against inserts and deletes elsewhere in the set, because the position is a value and not a count. It is not a snapshot: updated_at is mutable, so a row that is edited during the walk re-sorts and may be seen twice or not at all. If the sync job needs exactly-once coverage, order on an immutable key such as (created_at, resource_id), or walk resource_revision by revision_id and treat updated_at as data.
- Define termination and limits in the response, not in the client's inference: fetch n+1 rows, return n, and emit next_cursor only when the extra row existed. Absence of next_cursor is the sole end signal, because a page can legitimately come back short when rows are filtered after retrieval. Cap n and document the cap rather than honouring per_page=10000.
- Migrate without a flag day: keep page and per_page working, add the cursor, count usage per credential, and remove the offset path only once the sync job's traffic on it is zero.
Worked solution 25 min
- Write the old and new queries side by side and state the rows examined for page 400 under each.
- Define the cursor payload field by field, including the filter and sort fingerprint, and choose the encoding.
- Write the end-of-results rule and the cap, then the 400 response for a cursor that does not match the current query.
- Construct the mid-walk edit case: a row updated between page two and page three, and say exactly what the client sees.
- Write the deprecation plan for page and per_page, including the signal that says removal is safe.
Follow-up
- The client wants a total count and the ability to jump to page 400. What can you honestly offer instead, and what does each option cost?
- How do you paginate backwards, and what does that require of the index?
Read latency spikes on a sixty-second sawtooth
The cached listing read path serves about 14k reads/second at an 85% hit rate. p99 sits at 35 ms for 57 seconds, jumps to 900 ms for 3, and repeats. During each spike the primary shows several hundred identical listing queries starting within the same millisecond, all carrying one large tenant's id. Cache entries use a 60-second TTL. Give the mechanism, the ordered checks, the fix, and the correctness hazard your fix must not introduce.
Approach
- Match the period to a configured number before theorising about load. A spike every 60 seconds against a 60-second TTL is an entry expiring, and you confirm it by correlating spike timestamps with the entry's write time rather than with the traffic curve. If the period had matched a cron or a GC interval instead, this is a different investigation.
- Establish the concurrency of the miss. Several hundred identical queries in one millisecond means the miss path has no coalescing: every request that arrives between expiry and repopulation recomputes. The herd size is that key's arrival rate times its recompute time, so at 1.2k reads/second for the hot key and a 250 ms recompute you expect about 300 concurrent misses, which matches what is observed.
- Add single-flight on the miss path so one caller per key recomputes under a short-lived lock while the rest wait for its result. Prefer stale-while-revalidate where the read tolerates it: return the expired value immediately and refresh asynchronously, which removes the latency spike rather than serialising it into a queue of waiters.
- De-synchronise the keys. Write TTLs with jitter, for example 60 seconds plus or minus 10%, so a deploy or a mass invalidation does not align every key on the same second and turn a per-key herd into a fleet-wide one.
- Name the hazard the fix must not introduce. Serving a stale listing is acceptable only because the API reports the projection watermark, and a reader that loaded the old value before a write can repopulate the entry after the invalidation, so the bounded TTL is what actually caps staleness rather than the delete. Keep read-after-write pinned to the primary for the writing session regardless.
- Verify on miss concurrency, not hit rate. The hit rate barely moves, because the herd is one miss multiplied; the number that must change is distinct origin queries per key per minute.
Follow-up
- The same sawtooth appears on a key that is invalidated on write rather than expired. Is that the same bug?
- How does your answer change if the recompute takes 4 seconds instead of 250 ms?
- What exactly does a client see during a stale-while-revalidate window, and how does the watermark let them tell?
For a candidate senior enough that the loop turns on design and judgement rather than on whether the coding round gets finished. Five days build one system properly and then stress it; coding gets a single maintenance day, on the assumption that the risk at this level is an unexamined tradeoff rather than a missed algorithm.
Prepare, practise & reflect
One practical outcome each day. Spend longer where you need it.
0 / 7 done01Numbers before diagrams
- Build your own reference card of the figures you will re-derive all week: bytes for a realistic record, requests per second implied by a given daily active count, and the storage that a year at a given write rate produces. Derive each one rather than copying it, because the derivation is what survives a follow-up.
- Turn one product statement into capacity requirements. From ten million daily users at four writes and forty reads each, state the peak-to-average factor you are assuming and why, then produce peak write QPS, peak read QPS and a year of storage.
- Write the two numbers whose order of magnitude changes the design, the read-to-write ratio and the working-set size against memory per node, and state the threshold at which each one flips your answer.
Deliverable: A one-page numbers card and one worked capacity estimate with every assumption written down.
Practice prompt ↗Practice prompt ↗Worked solution ↗02One system, from requirements to schema
- Spend the first ten minutes producing only functional requirements, non-functional targets with numbers attached, a p99 latency, a durability expectation, a consistency requirement, and an explicit out-of-scope list.
- Define the interface before the boxes: the three or four endpoints, their parameters, what each returns, and which of them are idempotent.
- Write the data model, then write the single access pattern that justifies it, and state what the schema would have to become if the dominant access pattern were the other one.
Deliverable: One design carried to endpoint-and-schema depth, with non-functional targets expressed as numbers and a written out-of-scope list.
Practice prompt ↗Practice prompt ↗03The consistency you are actually buying
- Write out what a client sees under asynchronous replication when its write commits on the leader and its next read is served by a lagging follower, then write the two fixes, pinning that session's reads to the leader for a bounded window or carrying a version token the replica must reach, and the cost of each.
- Work the quorum arithmetic on paper for N of three with W and R of two, and separate what R + W > N does guarantee, that any read set intersects any write set, from what it does not: on its own it is not linearizability, and a sloppy quorum that accepts writes on nodes outside the preference list breaks even the intersection.
- Take two storage choices with different defaults, a single-leader relational store committing synchronously and a quorum-replicated store that converges eventually, and write the specific product behaviour that would be wrong under each, rather than a general statement about which is stronger.
Deliverable: A page separating what quorum overlap guarantees from what it does not, with one concrete product misbehaviour attached to each gap.
Practice prompt ↗Practice prompt ↗04Failure is the design
- For one write path, work through the case where the client times out after the server has already committed, then design the idempotency key: who generates it, how long it is retained, and what the duplicate request returns.
- Express the retry policy as parameters rather than as a word: maximum attempts, base delay, backoff factor, jitter, and which error classes are retried at all. Then state why retrying a non-idempotent write without a key is a correctness bug and not merely waste.
- Compute the fan-out effect on tail latency. If a request waits on ten backends and each independently exceeds its p99 one percent of the time, the chance at least one is slow is 1 - 0.99^10, about ten percent. Then write why independence is the optimistic assumption and what correlates them in practice.
- Name the backpressure mechanism for one queue or one dependency in the design, a bounded queue with shedding or a concurrency limit, and write what the caller is told when it engages.
Deliverable: One write path with an idempotency design, a parameterised retry policy, and a written tail-latency calculation with its assumption named.
Practice prompt ↗Practice prompt ↗Worked solution ↗05Scaling the hot path
- Choose cache-aside or write-through for one read path and write the staleness window each produces, then name the invalidation event and what the system does when that event is lost.
- Design against the stampede: either coalesce requests so only one recomputes a missing key, or refresh early with jittered expiry, and write why identical TTLs on keys populated in the same moment produce a synchronised expiry and a thundering herd.
- Shard one table by a key you choose, then answer the two questions that break the choice: which queries now require a scatter-gather, and what happens to the distribution when one tenant is a hundred times larger than the median.
- Write the cost of adding a node under plain modulo placement, where nearly every key moves, against consistent hashing, where roughly one key in n+1 moves, and state what virtual nodes are for.
Deliverable: A caching and sharding decision for one path, each with its failure mode and its rebalancing cost written beside it.
Practice prompt ↗Practice prompt ↗06Keep the coding hand in, at the bar that applies to you
- Solve one medium problem in thirty minutes, then spend twenty more making it production-shaped: named invariants, validation at the boundary, and errors that distinguish a caller mistake from an internal fault.
- Write the tests you would require of a colleague's version of that function: one for empty input, one for the boundary, and one for the case the implementation is most likely to get wrong.
- Read a piece of your own code from six months ago and write the change you would ask for, phrased as you would actually phrase it in review.
Deliverable: One problem hardened to review standard, with its test list and one written review comment.
Practice prompt ↗07Defend it while being interrupted
- Run a forty-five-minute design mock with an interviewer briefed to change a requirement halfway, a tenfold traffic increase or a new strict consistency requirement, and to push on one number you estimated.
- Rehearse the two sentences a senior loop is listening for: naming the tradeoff you are choosing against and why, and saying what you would measure to learn that the choice was wrong.
- Prepare the design you regret: a real decision, the constraint that produced it, what it cost, and what you changed afterwards.
Deliverable: Mock notes recording how the design changed under the new requirement, plus a written account of one regretted decision.
Practice prompt ↗Worked solution ↗Expand any day for tasks and deliverables. Your progress is saved on this device.
Every story you tell gets read for blast radius and judgement: what could have broken, who else it touched, what you knew at the moment you decided. Nobody can audit your code in an hour, so they audit your reasoning instead. Pick work where the call was genuinely yours and the consequences were real enough to remember.
How do you handle data imbalance in large-scale datasets?
How do you handle data imbalance in large-scale datasets?
Approach
- State the situation in two sentences and spend the rest on the reasoning.
- Close with what you would do differently, concretely.
- Name the disagreement and how you resolved it with evidence.
Follow-up
- How did you know your change caused the improvement?
- What did you decide not to do, and why?
Tell callers you do not own that their integration breaks
A field in a write endpoint's response must change shape. You own the endpoint; you do not own the four internal callers or the outbound webhook consumers who read it. Describe a deprecation you were responsible for: what you shipped first, how you established who was actually reading the field, the window you gave and what set its length, what you did about the consumer who never moved, and how you decided removal was safe. Name the signal you used, not the announcement you sent.
Approach
- Establish the reader set empirically rather than from a wiki of owners: per-field usage counters keyed by principal, or access logs attributed to a consumer. State the blind spot of whichever you pick, since a consumer that reads the field only on a monthly job will not appear in a week of logs.
- Ship additive first. Populate the new field alongside the old one so no reader is forced to move, which is also what keeps a rolling deploy safe, because old and new instances answer the same requests at the same time and a rollback must still find the old shape present.
- Set the window from the slowest legitimate consumer's release cadence, not from your calendar, and decide separately what to do for a consumer with no release process at all, such as an external webhook endpoint you can only email.
- Convert silence into evidence before you rely on it: a short, low-traffic removal window that makes a still-dependent consumer fail visibly and loudly while you are watching, rather than at three in the morning after you have moved on.
- State the removal criterion as a measurement with a duration attached, such as observed reads at zero across a full billing cycle, and keep the change reversible for one release after removal.
Follow-up
- How would you detect a consumer that reads the field only during a monthly export?
- One caller refuses to move and has a commercial relationship behind it. What changes in your plan and what does not?
- After removal, what makes the change irreversible, and how long before you cross that line?
Estimate work you have never done and defend the range
You are asked to estimate a change you have never attempted: add a column to a 100-million-row table, populate it, move reads across, and drop the old shape. Give a range with the assumptions that generate it, including batch size, the signal your backfill throttles on, and wall-clock hours, and name the three unknowns that would move the number most. Then describe a real estimate you gave under comparable ignorance: how you expressed its uncertainty, what you committed to, and how wrong you turned out to be.
Approach
- Decompose into independently deployable steps before estimating anything: add the column nullable, write both shapes, backfill in batches, verify, move reads, stop writing the old shape, drop it. That is four deploys spread over days, and the calendar estimate is dominated by them rather than by the loop's runtime.
- Do the arithmetic aloud for the part that has arithmetic in it: batch size times number of batches times per-batch duration, at a write rate the primary can absorb alongside roughly 1.2k writes per second of production traffic. The loop is throttled by replication lag and lock waits, not by how fast it can issue statements.
- Price the schema step by its lock rather than its statement duration. In PostgreSQL an ALTER TABLE taking ACCESS EXCLUSIVE waits for every open transaction on that table while later queries queue behind it, so a millisecond change issued during a thirty-second analytics query stalls that table for thirty seconds. Adding a nullable column with a non-volatile default avoids a rewrite from version 11; a new index wants CREATE INDEX CONCURRENTLY, which cannot run inside a transaction block and leaves an invalid index behind if it fails.
- Express the answer as a range whose endpoints each trace to a stated assumption, then name the cheapest experiment that collapses it, which is almost always running one real batch against the real table and multiplying.
- Commit to a checkpoint rather than a completion date: the day you report a measured number from that first batch. That is a promise you can keep under uncertainty, and it is what the asker actually needs in order to plan.
Follow-up
- How do you verify the backfill genuinely finished, given rows written by production traffic while it ran?
- Where does the backfill resume from after a worker is killed mid-batch, and what makes that resume point trustworthy?
- Your first batch comes back ten times slower than assumed. What do you tell the person waiting on the estimate, and when?
- 01
How do you handle data imbalance in large-scale datasets?
- 02
A field in a write endpoint's response must change shape. You own the endpoint; you do not own the four internal callers or the outbound webhook consumers who read it. Describe a deprecation you were responsible for: what you shipped first, how you established who was actually reading the field, the window you gave and what set its length, what you did about the consumer who never moved, and how you decided removal was safe. Name the signal you used, not the announcement you sent.
- 03
You are asked to estimate a change you have never attempted: add a column to a 100-million-row table, populate it, move reads across, and drop the old shape. Give a range with the assumptions that generate it, including batch size, the signal your backfill throttles on, and wall-clock hours, and name the three unknowns that would move the number most. Then describe a real estimate you gave under comparable ignorance: how you expressed its uncertainty, what you committed to, and how wrong you turned out to be.
Is this an official MSD interview guide?
No. It is PracHub's own research and practice material for the Machine Learning Engineer role at MSD. Rounds and questions reflect what candidates have reported, not a process MSD has published, and they change over time. Confirm the current format and scope with your recruiter.
PracHub interview research ↗How long does the interview process typically take?
Candidates typically report a process spanning a few weeks, though the initial timeline from recruiter contact to the first round can vary. Staying proactive in your communication with the recruiter helps maintain momentum.
PracHub interview research ↗What is the primary focus of the technical interviews?
The technical interviews are heavily weighted toward your past projects and your ability to code effectively. Expect to spend significant time discussing your technical decision-making process.
PracHub interview research ↗Is the culture at MSD collaborative?
Yes, feedback consistently highlights that team members are professional, polite, and passionate. They value candidates who show a collaborative spirit and a genuine interest in the company's mission.
PracHub interview research ↗Sources & methodology 3 sources ↗
No official company page is cited. Rounds and questions come from candidate reports and PracHub editorial material; each source shows the date it was read.
- 01PracHub interview research ↗
PracHub editorial research into this company and role, maintained with this guide. Candidate-reported, not an employer publication.
PracHub page · Accessed 2026-09-30 - 02PracHub Machine Learning Engineer practice ↗
Cross-company practice questions for this role.
PracHub page · Accessed 2026-09-30 - 03PracHub interview preparation framework ↗
The framework the preparation plan follows.
PracHub page · Accessed 2026-09-30