Novartis · Data Scientist
Updated · 2026-09-22

Novartis Data Scientist
Interview Questions & Guide 2026

THE 60-SECOND BRIEF

As a Data Scientist at Novartis, you play a critical role at the intersection of advanced computation, biomedical research, and global healthcare innovation. Your work directly empowers research and development teams to transform massive, complex scientific datasets into actionable insights, driving breakthroughs in drug discovery, clinical trials, and patient outcomes. You will operate within a high-impact environment where computational precision meets life-changing medical applications, influencing strategic pipelines from early-stage discovery to commercialization.

How much statistics you need depends on the flavour of the seat. Experiment-facing work wants you deep enough to notice that repeated looks at accumulating data inflate the false positive rate of a fixed-sample test; modelling-facing work wants estimation and honest uncertainty intervals.

Novartis candidates report 4 rounds · ≈ 3-5 weeks. The stages below are what candidates describe, not a published process.

Build member-month denominators from overlapping coverage spansCorrect for claims runout before reporting recent monthsMinimise protected health information in every extract

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See the practice prompts

17Practice promptsAcross five skill areas
3With worked solutionsIncluded in the practice prompts

As a Data Scientist at Novartis, you play a critical role at the intersection of advanced computation, biomedical research, and global healthcare innovation. Your work directly empowers research and development teams to transform massive, complex scientific datasets into actionable insights, driving breakthroughs in drug discovery, clinical trials, and patient outcomes. You will operate within a high-impact environment where computational precision meets life-changing medical applications, influencing strategic pipelines from early-stage discovery to commercialization.

This role requires you to tackle sophisticated scientific and operational problems, ranging from computer vision models for biomedical imaging to predictive time-series forecasting and robust clinical data analysis. You will collaborate closely with multidisciplinary teams—including domain experts, biomedical researchers, software engineers, and product managers—to design, deploy, and scale data-driven solutions. The complexity of the problem space demands both rigorous technical execution and a strategic product mindset to ensure your solutions deliver measurable value.

Expect a fast-paced yet collaborative culture that values intellectual curiosity, rigorous methodology, and scientific integrity. While the technical challenges are demanding, you will be supported by world-class infrastructure and talented peers who are deeply committed to reimagining medicine. Success in this position requires a balance of heavy technical capability, clear communication, and a genuine passion for applying data science to advance human health.

01

Initial Screening Call

reported

Whoever runs this call is usually not a practitioner. They take notes, and a hiring manager skims those notes later, so the real question is whether your work survives being written down by someone outside the field. Test every project sentence against that: could a non-specialist repeat it correctly without knowing what a propensity score is? Carry a plain-language version of each project and one reason you want this particular role that you could not copy onto another application. Vagueness at this stage reads as inexperience, even when the underlying work was genuinely deep.

What to demonstrate

  • Whether a non-specialist can restate your projects accurately, since their paraphrase is what reaches the hiring manager
  • Whether your reason for wanting the role points at the work itself rather than the company's reputation
  • Whether your language signals the level being screened for: what you decided yourself versus what you were handed

How to prepare

  • Write a two-sentence, jargon-free version of each major project: the question nobody could answer, and the decision your work changed. Read it to someone outside data and have them repeat it back
  • Point your 'why this role' answer at something concrete in the job description or the product surface you would be working on, and keep it to two sentences
  • Have two questions ready about measurement: which metric the team is held to, and who acts on an analysis once it lands
PracHub interview research ↗
02

Technical Assessments

reported

This round decides whether someone can hand you a schema and a question and trust the number that comes back. Correctness under a clock is the bar, not clever syntax. The habit that separates strong from weak answers is checking the grain: after every join, know how many rows you expect and whether the count moved. Most wrong answers in this format are not wrong logic, they are a fan-out from a key that turned out not to be unique, or a filter applied before an aggregate when it belonged after. Say what you expect before you run it.

What to demonstrate

  • Whether your row counts survive each join, and whether you notice on your own when they do not
  • Deliberate handling of rows that fail to match, including whether the question needs an inner join or a left join with the non-matches kept and counted
  • Whether NULLs are treated on purpose, given that a NULL compares equal to nothing and that COUNT of a column skips it
  • Reaching a defensible answer inside the window instead of a refined one after it

How to prepare

  • Take a two-table schema, write a join that fans out on purpose, then fix it by collapsing the many-side to one row per key before joining. Repeat until the fix is reflex rather than recall.
  • Write a funnel as one query and print the distinct user count at each stage, then confirm each stage is a subset of the one above it rather than assuming it
  • Do a few timed runs in a plain text box with no autocomplete and no formatter, since assessment editors often have neither
PracHub interview research ↗
03

Behavioral Questions

reported

Most of the weight in this round sits on the disagreement questions. Data work routinely produces an answer someone senior did not want, and the interviewer is trying to learn what you do in that hour. Both failure modes are common: folding as soon as a director pushes back, and treating the pushback as ignorance to be corrected with a better chart. A strong answer usually contains a specific thing the other person knew that you did not, and describes how you found out whether it changed the conclusion.

What to demonstrate

  • Whether you can state the other side's argument accurately before you explain why you disagreed
  • What you treated as evidence during the disagreement, such as a rerun under their assumption or a holdout check, rather than persuasion technique
  • Whether you distinguish being overruled from being wrong, and can give an example of each

How to prepare

  • Write out one disagreement where you turned out to be wrong, and say what in the data misled you. Candidates prepare the story where they were right, and the follow-up asks for the other one.
  • For your main disagreement story, be ready to say what result would have made you drop your position. If no such result exists, you were not arguing from the data.
  • Practise stating the opposing position out loud in one sentence the stakeholder would accept, then continue the story.
PracHub interview research ↗
04

Interviews with Team

reported

Because the format is not fixed, prepare the reasoning rather than the ritual. Nearly every version of this round draws on the same underlying material: a design you can defend, a metric you can define exactly, an analysis whose assumptions you can state out loud. Only the wrapper changes, whether that is a take-home, a live case, a deep dive on past work, or a rough estimate on a whiteboard. Answers rehearsed to fit one shape stall the moment the shape differs. Practise naming the assumption behind a number, then saying how much the conclusion moves if that assumption is wrong.

What to demonstrate

  • Whether your justification for a method survives the question 'why not the simpler thing', including when the simpler thing would have worked
  • Precision under pressure: what exactly counts as an active user, a conversion or a success, over what window, with what exclusions
  • Whether you carry an argument through to a recommendation instead of stopping at a list of tradeoffs

How to prepare

  • For each project you plan to mention, write the metric definition in one sentence: numerator, denominator, time window, exclusions. Say it out loud once, because vagueness shows up in speech before it shows up on paper.
  • Rehearse the same project at three lengths: two minutes, ten minutes, and a deep dive on one technical decision. Cutting live is harder than it sounds.
  • For your headline result, write down what would have had to be true for it to be wrong, and how you ruled that out.
PracHub interview research ↗

PracHub editorial advice for the preparation topics above.

01

Rates built on member counts rather than exposure

Members join and leave mid-period, so dividing events by distinct members mixes a person covered for 30 days with one covered for 365. New joiners also have artificially low observed utilisation because their claims have not arrived yet and because care takes time to initiate. Denominators must be member-months or member-years, and comparative quality measures usually need a continuous-enrolment requirement with an explicit allowable gap, stated in days.

02

Pre-post evaluation on a high-cost or high-risk cohort

Cohorts selected on an extreme value of the outcome regress toward the mean on their own. Members identified as the top 1 percent of spend in one year spend far less the next, whether or not anyone intervenes, because the selecting year captured both chronic severity and one-off events. A pre-post design on such a cohort will report savings every time. A concurrent comparison group selected by the same rule in the same period, or a regression discontinuity at the selection threshold, is the minimum credible design.

03

Answering a product-sense question with a list of features

Answer with a decision and the measurement that would settle it: the hypothesis, the primary metric, the guardrails, and the result that would make you not ship. A feature brainstorm cannot be wrong, which is exactly why it earns no points.

04

Generalising beyond the population the sample actually supports

State the frame the sample was drawn from and where it diverges from the population you want to talk about: time window, platform, geography, opt-in. If a group is excluded from the frame, either weight to known margins or narrow the claim rather than quietly extending it.

Choose a category, try a prompt, then open its approach, worked solution or follow-up when you need it.

14 technical prompts3 include a worked solution

How do classical machine learning algorithms like random forests and s…

medium
machine learning and modelling

How do classical machine learning algorithms like random forests and support vector machines function in real-world production environments compared to controlled settings?

Approach
  1. Frame the prediction: the label, the moment of prediction, and the action it triggers.
  2. Pick an evaluation metric that matches the cost of each error type, not a default.
  3. Say how the offline result would be validated online before it is trusted.
Follow-up
  • Where could label leakage enter this setup?
  • What would you monitor after launch to know the model is still valid?

Bootstrap a confidence interval for a ratio-of-sums PMPM

medium
bootstrapratio estimatorresampling unit

You have one row per member for a fully run-out incurred year: member_id, member_months, allowed_amount. Report allowed PMPM, defined as sum(allowed_amount) divided by sum(member_months), with a 95 percent confidence interval from a bootstrap you write yourself. No library resampler. Resample members with replacement, recompute the ratio on each of 2,000 replicates, take a percentile interval, and seed the generator so the result reproduces. In two sentences, state why resampling claim lines instead of members would be wrong.

Approach
  1. Name the estimator precisely: PMPM is a ratio of sums, not the mean of per-member ratios. The two differ whenever exposure correlates with spend, and it does, because members who churn out mid-year are systematically different from members covered all twelve months.
  2. Resample the unit of independence, which is the member, and recompute numerator and denominator together on the same draw. Recomputing only the numerator against a fixed denominator understates variance and is a common slip.
  3. Pull member_months and allowed_amount into numpy arrays once, then draw indices with rng.integers(0, n, size=n) per replicate. Index draws over arrays run one to two orders of magnitude faster than DataFrame.sample, which is the difference between 2,000 replicates and 200.
  4. Take the 2.5th and 97.5th percentiles of the replicate ratios. Expect an interval that is asymmetric around the point estimate, because healthcare spend is right skewed. That asymmetry is the method working, not a bug to centre away.
  5. Answer the line-resampling question concretely: the many lines of one high-cost member are not independent draws, so line resampling shrinks the interval toward zero width, and member_months has no line-level analogue, so the denominator becomes undefined.
Follow-up
  • Half a percent of members have a transplant or a long NICU stay. Does a percentile interval still have nominal coverage, and what would you do about the tail?
  • The question changes to comparing PMPM across provider panels. What becomes the resampling unit and why?
  • How would you use the same replicates to test whether this year's PMPM differs from last year's, given the same members appear in both?

Expand overlapping coverage spans into fractional member-months

mediumWorked solution
interval expansiondenominatorsvectorisation

member_enrollment has span_id, member_id, plan_id, product_type, effective_date, termination_date (NULL while active). Both dates are inclusive. Write a function returning one row per calendar month of a stated year with total member-months, where a member contributes covered days in the month divided by days in that month, capped at one month per member even when two spans overlap after a plan change or a retroactive span. Do not expand to one row per member-day: the sample has 400,000 members. Output: month, member_months.

Approach
  1. Resolve NULL termination_date to the reporting end date and say so in a comment. An open span is not an infinite span, and clipping it at the year end is what keeps the denominator finite and auditable.
  2. Merge overlapping and adjacent spans per member before touching months. Sort by member_id and effective_date, carry a running maximum of the end date, and open a new merged group when effective_date exceeds that running max plus one day. Adjacent means a gap of zero days, which a plan change produces constantly.
  3. Cross join the merged spans to the 12 month boundaries rather than to days. Overlap days = (min(span_end, month_end) - max(span_start, month_start)).days + 1, clipped below at 0. That is at most 12 rows per span instead of 365.
  4. Divide overlap days by the number of days in that month, so February and July are weighted correctly, then sum by month.
  5. Validate on a constructed member before trusting the aggregate: a single span covering the whole year must sum to exactly 12.0.
Worked solution 30 min
  1. Fill termination_date nulls with the reporting end date and clip all spans to the reporting year.
  2. Sort by member_id, effective_date, then compute a running max end per member with cummax shifted by one, flag a new group where effective_date > prior_max_end + 1 day, and cumsum the flag to get merged group ids.
  3. Aggregate each group to min start and max end, producing disjoint spans per member.
  4. Cross join merged spans to a 12-row month frame, compute clipped overlap days, divide by days in month.
  5. Group by month and sum.
EXPECTED RESULTTwelve rows. For a member with spans 2026-01-01 to 2026-03-15 and 2026-03-01 to 2026-06-30, March contributes exactly 1.0, not 15/31 plus 31/31. For a member with spans covering January and March only, January is 1.0, February is 0.0, March is 1.0, and the member totals 2.0.
Follow-up
  • Product type changes mid-year. The metric must be reported by product_type. Where does the cap now apply and what breaks?
  • An eligibility file arrives with a retroactive termination that shortens a span you already reported on. How do you restate?
  • Why member-months rather than distinct members, in one sentence, for a director who wants the simpler number?

Roughly 90 minutes a night on weekdays with one longer weekend block. The plan deliberately cuts scope rather than compressing everything, on the assumption that finishing one thing a night beats half-starting four.

Small steps. Visible outcomes.0 / 7 completed
ONE WEEK · YOUR PACE

Prepare, practise & reflect

One practical outcome each day. Spend longer where you need it.

0 / 7 done
01Fix the scope and set a baseline
  • Read the role description and write the three things the loop will almost certainly test, then write an explicit not-doing list for everything else and keep it visible all week.
  • Take one 20-minute SQL prompt and one 10-minute metric question cold, and write the single sentence that says what blocked each attempt, since that sentence is what decides which two topics get the most evenings.
  • Set the week's one rule: one problem finished to completion every night, including the night you only have 40 minutes.

Deliverable: A one-page scope with an explicit not-doing list and two cold attempts, each carrying one sentence on what blocked it.

Practice prompt ↗Practice prompt ↗Practice prompt ↗Worked solution ↗
02One query pattern, written three times
  • Choose the single pattern most likely to appear (a cohort retention grid, or a funnel counted by user) and write it three times from a blank file rather than editing the previous attempt.
  • On the third attempt, write the grain of every CTE as a comment before writing its body.
  • Stop at 90 minutes even if the third version is imperfect, and write the one thing you would fix with another hour.

Deliverable: Three independent versions of the same query plus a note on what changed between them.

Practice prompt ↗Practice prompt ↗Practice prompt ↗
03Only the statistics you will be asked to defend
  • Write, in under 200 words, how you would decide whether a difference between two groups is real: the test, its assumptions, and what you would switch to when an assumption fails.
  • Compute a 95 percent confidence interval for a difference in proportions by hand on realistic numbers, then write in one sentence what changes if the two samples are paired rather than independent.
  • Write your answer to "what does a p-value mean", check it against a definition, and delete the version that describes it as the probability the hypothesis is true.

Deliverable: A 200-word written answer and one hand-computed interval you can reproduce under pressure.

Practice prompt ↗Practice prompt ↗Practice prompt ↗
04One case, and the assumptions holding it up
  • Answer one product case aloud in 20 minutes with a recording running, then listen back with a pen and mark every claim you asserted without saying what it rested on: an assumed user behaviour, an assumed data source, an assumed baseline rate, an assumed grain.
  • Pick the three assumptions the recommendation actually depends on, write how you would check each one against data, and say which one being wrong would flip the recommendation rather than merely weaken it.
  • Write the four-step structure you used onto a card small enough to hold in working memory when you are nervous.

Deliverable: One recording, three load-bearing assumptions each with a written check, and a four-step structure card.

Practice prompt ↗Practice prompt ↗Worked solution ↗
05Your own work, timed
  • Write a 90-second version and a four-minute version of your main project, and time both out loud rather than reading them.
  • Prepare answers to the two follow-ups that always come: what you would do differently, and how you knew it worked.
  • Put one number in the first sentence and be able to say exactly where that number came from and what it excludes.

Deliverable: Two timed narratives with one defensible number in the opening line.

Practice prompt ↗Practice prompt ↗
06The one full rehearsal, in a longer weekend block
  • Run a 60-minute mock covering query work, a case and a behavioural question in a single sitting with no breaks, because sustained attention is the thing evenings have not trained.
  • Immediately afterwards, and before hearing any feedback, write the three moments you lost the thread.
  • Spend the rest of the block only on those three moments, and on nothing you merely feel shaky about.

Deliverable: Mock notes naming three failure moments with a specific fix written under each.

Practice prompt ↗Practice prompt ↗
07Taper
  • Write the 20-minute warm-up you will actually do on the morning of the interview: one query you can already write from a blank file, one metric you can define out loud, and nothing you have never seen before.
  • Re-read only your own notes from this week, and open no new material.
  • Write down the logistics: the tool you will be asked to work in, whether lookups are allowed, and the sentence you will use when you do not know something.

Deliverable: A one-page card holding the case structure, the project numbers, and the logistics.

Practice prompt ↗Practice prompt ↗Worked solution ↗

Expand any day for tasks and deliverables. Your progress is saved on this device.

Work that nobody used is a common and unflattering pattern in data careers, and interviewers probe for it. Have a story about an analysis that changed a decision, and be specific about how you got it in front of the person who could act. Also have one about work that went nowhere, with your reading of why.

Walk us through a past research or engineering project where you had t…

medium
behavioural and stakeholder questions

Walk us through a past research or engineering project where you had to navigate severe ambiguity or shifting requirements.

Approach
  1. State the situation in two sentences and spend the rest on your reasoning.
  2. Name the disagreement or constraint, and how you resolved it with evidence.
  3. Quantify the outcome, including what you would not claim credit for.
Follow-up
  • What did you decide not to do, and why?
  • How did you know the outcome was caused by your change?

Own an analysis that shipped wrong and was acted on

easy
retrospectiveownershipdata quality

Describe an analysis you delivered that was wrong, where someone acted on it before the error surfaced. Pick something with a mechanism you can name, not a typo. Cover what the number claimed, what was actually true, how much time passed before it was caught, who caught it, and what you told the people who had already acted. Deliverable: a five-minute account that ends with the specific control you added afterwards, plus one occasion since when that control has fired.

Approach
  1. Read the probe: the interviewer is testing whether you detect your own errors and whether the correction was structural. Pick an error with a nameable mechanism (a denominator built from distinct members instead of member-months, a series read before claims runout completed, a cohort selected on the outcome) so the story has a diagnosis rather than a mood.
  2. Open with the decision that was made on your number, not with the bug. The severity of an analytic error is measured in the action it caused: a rate filing, a staffing plan, a programme expansion.
  3. State the counterfactual number. 'The true figure was 14.1 admissions per 1,000 member-years, not 9.8' is a fact; 'it was off by a lot' is not.
  4. Describe the detection path honestly, including whether you found it or somebody else did. Say how long it took, because time to detection is the part you actually control next time.
  5. Close on the control, and make it something that protects a reader who has never met you: a unit test on the denominator, a paid-through date stamped on every chart, a required exclusions block in the spec template. Name one later date it caught something.
Follow-up
  • What would have had to be true for you to catch this before delivery rather than after?
  • Did the stakeholder change how much they trust your work, and did you want them to?
  • Give an example of a control you added that turned out to be the wrong control.

Disagree with a product manager about an adherence nudge

medium
immortal timeconfoundingdisagreement

A product manager proposes shipping a refill-reminder feature to the whole member base, citing an internal analysis: members with 12-month proportion of days covered at or above 0.80 had 31 percent fewer admissions than members below it. The roadmap date is three weeks out and engineering is scoped. You believe the comparison builds survival and continuous coverage into the exposure definition, and is separately confounded by the kind of member who refills on time. Deliverable: what you say in the room, what you send afterwards, and the smallest study you would accept as sufficient to ship.

Approach
  1. The probe is whether you can be specific and non-territorial at once. A disagreement that arrives as 'the analysis is flawed' costs you the room; one that names a mechanism and offers a cheaper path keeps it.
  2. Name the two defects separately, because they have different fixes. Classifying a member as adherent over 12 months requires them to stay alive and stay covered for those 12 months, and that guaranteed event-free interval is assigned to the adherent group. Separately, members who refill on schedule differ from those who do not in ways claims never record.
  3. Show rather than assert. Rerun the same comparison as a landmark analysis: classify adherence over days 1 to 90, start follow-up at day 91 for everyone still enrolled and event-free, and report how much of the 31 percent survives.
  4. Separate the association claim from the intervention claim out loud. Nothing in the analysis speaks to whether a reminder changes refill behaviour, which is the actual product question and is separately testable.
  5. Offer the shippable path: a randomised holdout on a subset with proportion of days covered as the primary endpoint, powered on the plausible effect of a reminder rather than on the 31 percent, with a stated read date.
Follow-up
  • The landmark rerun still shows a 20 percent difference. Do you ship?
  • The product manager says a holdout delays launch. How do you cost that argument?
  • What primary endpoint do you choose, and why not admissions?
  • 01

    Walk us through a past research or engineering project where you had to navigate severe ambiguity or shifting requirements.

  • 02

    Describe an analysis you delivered that was wrong, where someone acted on it before the error surfaced. Pick something with a mechanism you can name, not a typo. Cover what the number claimed, what was actually true, how much time passed before it was caught, who caught it, and what you told the people who had already acted. Deliverable: a five-minute account that ends with the specific control you added afterwards, plus one occasion since when that control has fired.

  • 03

    A product manager proposes shipping a refill-reminder feature to the whole member base, citing an internal analysis: members with 12-month proportion of days covered at or above 0.80 had 31 percent fewer admissions than members below it. The roadmap date is three weeks out and engineering is scoped. You believe the comparison builds survival and continuous coverage into the exposure definition, and is separately confounded by the kind of member who refills on time. Deliverable: what you say in the room, what you send afterwards, and the smallest study you would accept as sufficient to ship.

PracHub interview preparation framework ↗
Is this an official Novartis interview guide?

No. It is PracHub's own research and practice material for the Data Scientist role at Novartis. Rounds and questions reflect what candidates have reported, not a process Novartis has published, and they change over time. Confirm the current format and scope with your recruiter.

PracHub interview research ↗
How difficult are the technical interviews at Novartis?

The interviews are moderately to highly rigorous, focusing heavily on your practical problem-solving abilities and foundational understanding rather than trick questions. Expect deep scrutiny of your past projects, requiring you to justify your methodological choices and architectural designs.

PracHub interview research ↗
How much preparation time should I plan for?

Most candidates benefit from 4 to 6 weeks of dedicated preparation. Use this time to brush up on core statistics, practice coding challenges involving SQL window functions, and refine your behavioral narratives around project ownership and handling mistakes.

PracHub interview research ↗
What distinguishes successful candidates from those who are passed over?

Successful candidates demonstrate a holistic understanding of the data lifecycle, combining strong technical execution with a clear product and scientific mindset. They communicate their reasoning transparently, embrace collaborative problem-solving, and connect their technical work back to real-world impact.

PracHub interview research ↗
What is the typical interview timeline from screening to offer?

The timeline can vary, typically spanning 3 to 6 weeks from your initial recruiter screening through technical rounds, take-home or live coding assessments, and final stakeholder interviews. Some loops move swiftly, while others involve coordination across multiple internal teams.

PracHub interview research ↗
Sources & methodology 3 sources ↗

No official company page is cited. Rounds and questions come from candidate reports and PracHub editorial material; each source shows the date it was read.