Novo Nordisk · Machine Learning Engineer
Updated · 2026-10-02

Novo Nordisk Machine Learning Engineer
Interview Questions & Guide 2026

THE 60-SECOND BRIEF

As a Machine Learning Engineer at Novo Nordisk, you are at the forefront of transforming global healthcare. Your work directly accelerates life-saving drug discovery, optimizes complex clinical trials, and streamlines a massive global supply chain. This is not just a standard tech role; it is an opportunity to apply advanced artificial intelligence to biological data, clinical outcomes, and pharmaceutical operations, ultimately improving the lives of millions of patients worldwide.

If the seat owns a service boundary, scope your preparation toward failure behaviour rather than topology. Retrying over an at-least-once channel produces duplicates by construction, so a retry policy is only as safe as the idempotency key underneath it.

Novo Nordisk candidates report 4 rounds · ≈ 3-5 weeks. The stages below are what candidates describe, not a published process.

Make every write idempotent under retryBound every outbound call with a timeoutDetect concurrent edits instead of losing writes

37 min read

Browse Machine Learning Engineer questions

See the practice prompts

16Practice promptsAcross five skill areas
3With worked solutionsIncluded in the practice prompts

As a Machine Learning Engineer at Novo Nordisk, you are at the forefront of transforming global healthcare. Your work directly accelerates life-saving drug discovery, optimizes complex clinical trials, and streamlines a massive global supply chain. This is not just a standard tech role; it is an opportunity to apply advanced artificial intelligence to biological data, clinical outcomes, and pharmaceutical operations, ultimately improving the lives of millions of patients worldwide.

Novo Nordisk relies on its engineering teams to bridge the gap between theoretical data science and robust, production-ready healthcare solutions. You will be responsible for scaling models, ensuring rigorous compliance with medical data regulations, and building the infrastructure that allows researchers and data scientists to deploy their insights efficiently. The scale and complexity of the data you will handle require both deep technical expertise and a strong sense of purpose.

Expect a highly collaborative, cross-functional environment. You will work alongside domain experts—such as computational biologists, pharmacologists, and data scientists—translating their research into scalable software. A successful here is not only an excellent coder but also a strategic thinker who understands how model architecture impacts real-world medical and business outcomes.

01

HR Phone Screen

reported

The person on this call usually cannot evaluate your code and does not need to. They write a short paragraph, and that paragraph is what a hiring manager skims when deciding who to put on your loop. So the test is not whether your work was hard, it is whether a non-engineer can repeat it correctly. Name systems by what they did rather than by their internal codename, give each project a shape (what was breaking, what you changed, what happened after), and keep the whole walkthrough near ninety seconds. Depth that cannot survive a paraphrase reads as vagueness.

What to demonstrate

  • Whether a non-engineer can restate your projects without distorting them, since their paraphrase is what travels to the hiring manager, not your sentences
  • Whether each project has a shape rather than a stack list: the failure or constraint, the change you made, the result and how it was measured
  • Whether you can say what was yours inside a team project without either inflating it or disappearing into the plural

How to prepare

  • Rewrite each headline project as two sentences with no internal system names and no acronyms outside your company, then say them to someone outside engineering and have them repeat them back. Fix whatever came back wrong
  • Attach one measured number to each project: the baseline, the change, and the window it was measured over. Where nothing was ever measured, say that plainly rather than reaching for a plausible percentage
  • Time the background walkthrough against a clock. If it runs past two minutes, compress the earliest role to a single clause and spend the recovered time on the most recent one
PracHub interview research ↗
02

One-on-One Technical Round

reported

The same problem is scored by two different mechanisms depending on the format, and preparing for one does not cover the other. With a person watching, partial progress is visible and a hint is a correction you can absorb; silence is the expensive failure, because nobody can read a half-written function. With an automated grader there is no partial credit for what you were about to do, nobody to ask, and the worked examples in the prompt are the entire specification. Read them as a contract, down to whether an empty result should be an empty list or no output at all.

What to demonstrate

  • In a live session, whether your commentary tracks what your hands are doing, and whether a hint redirects you or gets defended against
  • In an automated one, whether you cover the cases the examples do not show, since the hidden cases are where the score moves
  • Whether you manage the clock on purpose: abandoning an approach that is not converging while there is still time to write something simpler that finishes

How to prepare

  • Have someone hand you a problem and feed you one deliberately wrong hint. Practise testing it against a concrete case instead of accepting or rejecting it on authority.
  • Do one timed run a week in a plain browser editor with autocomplete, linting and your own snippets switched off, which is closer to what these environments give you
  • For the automated format, write the harness before the solution: a main that feeds the worked examples plus an empty and a single-element case and prints expected against actual, so a wrong submission is caught by you first
PracHub interview research ↗
03

Panel Interview

reported

Coding rounds mostly set a floor. They decide whether you clear the bar, not where you land on the ladder. Level tends to come out of the design discussion and the ownership stories, so the question worth auditing beforehand is whether the scope you describe matches the scope of the job. Work that stops at your own service, or a story whose hard part was writing the code rather than getting several people to agree on an interface, reads a level below where you think you are interviewing, and that gap is usually resolved downwards.

What to demonstrate

  • Whether the largest thing you describe owning ran end to end — the decision, the migration path, the rollout, and what you did when it went wrong — or stopped at the change you merged
  • Whether design answers include what you would not build, what you would defer, and what you would measure before committing, rather than only what the boxes are
  • Whether a disagreement in a story was settled with something checkable — a benchmark, a prototype, a written proposal — instead of by seniority or by waiting it out
  • Whether you can say which calls you made alone and which you escalated, and why the line sat where it did

How to prepare

  • Write your largest piece of owned work as a timeline of decisions — who decided what, when, and what you did when the plan broke — then delete every sentence whose subject is "we" and see how much survives
  • Take one system you know well and drill the migration answer: how old and new paths run side by side under live traffic, how you compare their outputs, what the rollback is once writes are going to both, and which step you would not automate
  • Map each line of the ladder in the job posting to a specific thing you have done, find the line you cannot support, and prepare the closest evidence you have plus an honest account of the gap
PracHub interview research ↗
04

Comprehensive HR Round

reported

What you say here is written down by each interviewer and compared afterwards, so the unit of evaluation is a claim someone else could check, not a well-told narrative. Two things make a story checkable: detail only a participant would hold, and a clean line around which part was yours. Vague ownership is the usual failure and it is usually accidental, because engineers say we about the team's work and we about their own, so the thing they personally built disappears into the plural. Name the part you wrote, and name who did the rest.

What to demonstrate

  • Whether your details are ones a participant would hold and an observer would not: the constraint that ruled out the obvious approach, the first attempt that failed, the person who objected and on what grounds
  • Whether ownership survives a direct question, since a follow-up to we decided is routinely who decided, and an answer that stays plural at that point is read as the work belonging to someone else
  • Whether the numbers you quote are ones you would say identically to a former colleague with the dashboard open

How to prepare

  • Go through each story replacing every we with either I or a named role (the on-call engineer, the reviewer, the other team) and check the story still holds together. Wherever it stops making sense you have found a part you cannot actually speak to
  • Open the artefacts for two of your stories, the pull request, the design doc, the incident notes, and read them for dates and figures you have been rounding in the retelling. Correct your version to match
  • For each story write the single sentence you would least want repeated to a former teammate, then either make it accurate or take it out
PracHub interview research ↗

PracHub editorial advice for the preparation topics above.

01

Assuming an isolation level prevents the anomaly you actually have

Isolation levels are named by the SQL standard but implemented differently, so any claim about one is only true of a named engine. PostgreSQL defaults to READ COMMITTED, where every statement takes a fresh snapshot, so two statements inside one transaction can legitimately disagree about the same row. Its REPEATABLE READ is snapshot isolation: it removes non-repeatable and phantom reads but permits write skew, where two transactions each read a set, each conclude their own write is safe, both commit, and the combined result violates a constraint that no single row expresses. Only SERIALIZABLE closes that, and it closes it by aborting a transaction with a serialization failure (SQLSTATE 40001), which means the guarantee is theoretical unless the application has a retry loop. InnoDB's REPEATABLE READ is a different mechanism again - plain SELECTs read a consistent snapshot while locking reads and writes see the latest committed row - so a read-modify-write inside one transaction can act on a value that the transaction's own earlier SELECT never returned.

02

Paginating with LIMIT/OFFSET over a set that changes while the client is reading it

OFFSET n makes the database produce and discard n rows before returning anything, so the cost of a page grows with its depth rather than with its size and page 500 costs five hundred pages of work. The correctness problem is worse than the cost: if a row is inserted or reordered between two page fetches, rows shift across the offset boundary and are either skipped entirely or returned twice, and neither outcome leaves any trace in the response for the client to detect. Keyset pagination - WHERE (sort_key, id) < ($last_sort_key, $last_id) ORDER BY sort_key DESC, id DESC LIMIT n, backed by an index in exactly that order - reads only the rows it returns and is stable against concurrent inserts. It requires the tie-break column: a timestamp is not unique, and duplicate sort keys straddling a page boundary reintroduce the skip it was adopted to remove.

03

Starting work without saying what you are about to spend time on

State the plan before executing it: the approach, roughly how long it will take, and what you intend to leave hand-waved. That gives the interviewer a chance to redirect you in ten seconds rather than watching you spend fifteen minutes on the wrong sub-problem.

04

A cache with no invalidation story

Say how an entry goes stale, how long you can serve it stale, and what happens when many requests miss the same key at the same instant. One popular key expiring under load sends every concurrent request to the origin together; single-flight coalescing, jittered expiry, or serving stale while revalidating are the standard answers.

Choose a category, try a prompt, then open its approach, worked solution or follow-up when you need it.

13 technical prompts3 include a worked solution

Why did you choose this specific model architecture over a simpler bas…

medium
machine learning fundamentals

Why did you choose this specific model architecture over a simpler baseline?

Approach
  1. Name the simplest model that could work and what would make you move past it.
  2. Say how you would validate it, and where leakage could enter the split.
  3. State the learning problem: the label, the unit of prediction and how the model is used.
Follow-up
  • Where could label leakage enter this setup?
  • How would you know the model is overfitting?

What was the primary business impact of the model you deployed in your…

medium
machine learning fundamentals

What was the primary business impact of the model you deployed in your previous role?

Approach
  1. Pick the metric from the cost of each error type, not from habit.
  2. Name the simplest model that could work and what would make you move past it.
  3. State the learning problem: the label, the unit of prediction and how the model is used.
Follow-up
  • Where could label leakage enter this setup?
  • How would you know the model is overfitting?

What evaluation metrics did you use, and why were they the most approp…

medium
machine learning fundamentals

What evaluation metrics did you use, and why were they the most appropriate for this business problem?

Approach
  1. Name the simplest model that could work and what would make you move past it.
  2. Say how you would validate it, and where leakage could enter the split.
  3. Pick the metric from the cost of each error type, not from habit.
Follow-up
  • How would you know the model is overfitting?
  • Where could label leakage enter this setup?

How did you handle missing or noisy data in this specific dataset?

medium
machine learning fundamentals

How did you handle missing or noisy data in this specific dataset?

Approach
  1. Pick the metric from the cost of each error type, not from habit.
  2. Say how you would validate it, and where leakage could enter the split.
  3. State the learning problem: the label, the unit of prediction and how the model is used.
Follow-up
  • How would you know the model is overfitting?
  • What changes if the classes are heavily imbalanced?

Archive a resource graph without breaking live references or recursing

mediumWorked solution
graph traversaltopological ordertenant isolation

Resources reference other resources within a tenant; for the largest tenant the reference table holds up to 2,000,000 nodes and 8,000,000 edges. Archiving a resource must archive everything reachable from it that nothing outside the set still references, refuse when a live external referrer exists, and terminate when references form cycles, which they legitimately do. Produce the archive order and the refusal list, targeting O(V+E). Say what stops the traversal crossing a tenant boundary, and why recursion is the wrong control structure at this size.

Approach
  1. Load the subgraph with the tenant predicate on both endpoints of the edge, not only on the side you started from. Scoping the left table alone is the classic cross-tenant leak: one mis-entered edge then pulls another tenant's resources into the traversal and, worse, into the archive.
  2. Traverse iteratively with an explicit stack. A 2,000,000-node graph can hold a chain deep enough to exhaust a native stack in the low tens of thousands of frames, and that failure is a process crash rather than an error you can return.
  3. Treat cycles as data rather than corruption: compute strongly connected components with Tarjan in O(V+E) using its own explicit stack, then condense. The condensation is a DAG, so a topological order over it gives the archive order, and every member of a component archives in one transaction because no order within a cycle is valid.
  4. Decide refusals with reverse edges. A candidate is archivable only if every in-edge originates inside the candidate set, so build the transpose or count in-degrees restricted to the visited set, and emit each blocked resource with the id of the external referrer, which is the only part of the answer an operator can act on.
  5. Store the graph as CSR rather than a map of lists: an offsets array of V+1 8-byte entries plus E 8-byte targets is about 80 MB at this size, where boxed adjacency lists cost several times that and lose cache locality on every hop.
  6. Run Kahn over the condensation for the order in O(V+E). If the emitted count is short of the component count the condensation step itself is wrong, since a condensation cannot contain a cycle, which makes the check free.
Worked solution 30 min
  1. Write the edge-loading query with the tenant predicate on both endpoints and state what it does with a cross-tenant edge.
  2. Implement iterative Tarjan with an explicit stack and confirm on a three-node cycle that it emits one component of size three.
  3. Build the transpose restricted to the visited set and mark every node with an in-edge from outside it as refused, carrying the referrer id.
  4. Run Kahn over the condensation and verify the emitted order against the referrer-before-referenced rule.
  5. Size the CSR arrays for 2,000,000 nodes and 8,000,000 edges and compare against a boxed adjacency map.
EXPECTED RESULTAn iterative O(V+E) traversal over a tenant-scoped CSR subgraph, SCC condensation so cycles archive atomically as one component, a transpose-based refusal list naming the external referrer for each blocked resource, and a Kahn topological order over the condensation, with recursion replaced by an explicit stack because of graph depth rather than style.
Follow-up
  • The graph is read in one query and the archive writes a minute later. What can change in between, and how do you make the write safe?
  • The candidate set is 400,000 resources. Is that one transaction, and if not, what does a half-finished archive look like to a reader?
  • An edge points at a resource in another tenant. Is that a refusal, an error, or an alert?

Roughly ninety minutes on weeknights with one longer weekend block. The plan cuts scope rather than compressing everything, on the assumption that one thing finished per night beats four half-started.

Small steps. Visible outcomes.0 / 7 completed
ONE WEEK · YOUR PACE

Prepare, practise & reflect

One practical outcome each day. Spend longer where you need it.

0 / 7 done
01Fix the scope and take a cold baseline
  • Read the role description and write the three things the loop will almost certainly test, then write an explicit not-doing list and keep it visible all week.
  • Take one twenty-five-minute coding problem and one fifteen-minute design prompt cold, and write the single sentence naming what blocked each, because those two sentences decide where the remaining evenings go.
  • Set the week's rule: one thing finished every night, including the night you only have forty minutes.

Deliverable: A one-page scope with a not-doing list and two cold attempts, each carrying one sentence on what blocked it.

Practice prompt ↗Practice prompt ↗Practice prompt ↗Worked solution ↗
02One pattern, written three times from blank
  • Choose the single pattern most likely to appear in your loop and write it three times from an empty file rather than editing the previous attempt.
  • On the third pass, write the invariant as a comment before the loop body and the complexity before the first line of code.
  • Stop at ninety minutes even if the third version is imperfect, and write the one thing you would fix given another hour.

Deliverable: Three independent implementations of the same pattern plus a note on what changed between them.

Practice prompt ↗Practice prompt ↗Practice prompt ↗
03One design, only to the depth you can defend
  • Take one system shape and go only as far as requirements, interface and data model, refusing to draw a box you could not survive a follow-up about.
  • Attach one number to each non-functional requirement, deriving it rather than asserting it, and write the assumption the number rests on.
  • Write the one tradeoff you are choosing against and the observation that would make you reverse it.

Deliverable: One design at interface-and-schema depth with derived numbers and one written reversible tradeoff.

Practice prompt ↗Practice prompt ↗
04Only the fundamentals you will have to defend
  • Write, in under two hundred words each, the answers to the two questions that follow almost any implementation: why this structure and not the obvious alternative, and what happens to this code at a hundred times the input.
  • Write what an index actually costs: faster lookups on the indexed columns against a write that now maintains a second structure, plus the cases where the planner declines to use it anyway, low selectivity, or a predicate wrapping the column in a function.
  • Delete any answer you cannot deliver aloud in under a minute, since an answer that needs reading is not an answer you have.

Deliverable: Three written answers, each under two hundred words and each timed aloud.

Practice prompt ↗Practice prompt ↗Worked solution ↗
05Your own work, timed
  • Write a ninety-second and a four-minute version of your main project and time both aloud rather than reading them.
  • Prepare the two follow-ups that always come: what you would do differently, and how you knew it worked.
  • Put one number in the first sentence and be ready to say exactly where it came from and what it excludes.

Deliverable: Two timed narratives with one defensible number in the opening line.

Practice prompt ↗Practice prompt ↗
06The one full rehearsal, in the weekend block
  • Run a sixty-minute mock covering a coding round and a design round in one sitting with no break, because sustained attention is the thing evenings have not trained.
  • Immediately afterwards, and before hearing any feedback, write the three moments you lost the thread.
  • Spend the rest of the block only on those three moments, and on nothing you merely feel shaky about.

Deliverable: Mock notes naming three failure moments with a specific fix written under each.

Practice prompt ↗Practice prompt ↗
07Taper
  • Write the twenty-minute warm-up you will actually do on the morning: one problem you can already solve from a blank file, one design you can narrate, and nothing you have never seen.
  • Re-read only your own notes from this week and open no new material.
  • Write the logistics down: the editor or shared document you will be working in, whether execution and lookups are permitted, and the sentence you will use when you do not know something.

Deliverable: A one-page card holding the design structure, the project numbers, and the logistics.

Practice prompt ↗Practice prompt ↗Worked solution ↗

Expand any day for tasks and deliverables. Your progress is saved on this device.

A slipped date is only a bad story if you sat on it. What matters is what you believed when you gave the number, the signal that told you it was wrong, how many days passed before you said so, and what you cut rather than asking for more time. Scope you defended counts as much as scope you dropped.

Describe a time you had to explain a complex machine learning failure …

medium
behavioural and collaboration

Describe a time you had to explain a complex machine learning failure to a non-technical stakeholder.

Approach
  1. Give the blast radius: what could have broken, and what you measured.
  2. Close with what you would do differently, concretely.
  3. Name the disagreement and how you resolved it with evidence.
Follow-up
  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

Narrate an outage you owned from page to postmortem

hard
incident responseblast radiuspostmortems

Pick an incident you personally drove, ideally one where writes were affected rather than reads. In six to eight minutes: state the symptom as it first appeared on a dashboard, the blast radius you established before you knew the cause, the mitigation you applied and when, the mechanism you eventually proved, and the follow-up that would prevent a repeat. Bring numbers: error rate, tenants affected, minutes to mitigate, minutes to resolve. If you cannot name what you measured, choose a different incident.

Approach
  1. Open on the signal rather than the cause: which metric at which percentile moved, on which service, at what time, so the listener follows the same evidence you had rather than a conclusion you already reached.
  2. Separate mitigation from diagnosis out loud. State what you did to stop the bleeding (flag off, shed traffic, drain a lease, roll back a deploy) and say plainly that you did it before the mechanism was known, because those are two jobs with different deadlines.
  3. Establish blast radius in countable terms: how many tenants, how many writes, and crucially whether the effect was loss or only delay. An append-only revision table or a pending outbox row means the change survived and the projection was merely behind, which is a repair rather than a data-loss incident.
  4. Prove the mechanism instead of asserting it. Name the trace span that grew, the plan that flipped to a sequential scan, the lease that expired, plus one alternative you ruled out and the signal that stayed flat while you ruled it out.
  5. Close on the durable fix and its cost, distinguishing what landed that week from what needed an expand-and-contract migration across several deploys, and say which of the two you actually finished.
Follow-up
  • What would you do differently in the first five minutes, given the same dashboard and no more information?
  • Which follow-up action did you deliberately not take, and why was dropping it the right call?
  • How did you convince yourself the mitigation was safe to apply while the cause was still unknown?

Tell callers you do not own that their integration breaks

medium
deprecationcompatibilitystakeholders

A field in a write endpoint's response must change shape. You own the endpoint; you do not own the four internal callers or the outbound webhook consumers who read it. Describe a deprecation you were responsible for: what you shipped first, how you established who was actually reading the field, the window you gave and what set its length, what you did about the consumer who never moved, and how you decided removal was safe. Name the signal you used, not the announcement you sent.

Approach
  1. Establish the reader set empirically rather than from a wiki of owners: per-field usage counters keyed by principal, or access logs attributed to a consumer. State the blind spot of whichever you pick, since a consumer that reads the field only on a monthly job will not appear in a week of logs.
  2. Ship additive first. Populate the new field alongside the old one so no reader is forced to move, which is also what keeps a rolling deploy safe, because old and new instances answer the same requests at the same time and a rollback must still find the old shape present.
  3. Set the window from the slowest legitimate consumer's release cadence, not from your calendar, and decide separately what to do for a consumer with no release process at all, such as an external webhook endpoint you can only email.
  4. Convert silence into evidence before you rely on it: a short, low-traffic removal window that makes a still-dependent consumer fail visibly and loudly while you are watching, rather than at three in the morning after you have moved on.
  5. State the removal criterion as a measurement with a duration attached, such as observed reads at zero across a full billing cycle, and keep the change reversible for one release after removal.
Follow-up
  • How would you detect a consumer that reads the field only during a monthly export?
  • One caller refuses to move and has a commercial relationship behind it. What changes in your plan and what does not?
  • After removal, what makes the change irreversible, and how long before you cross that line?
  • 01

    Describe a time you had to explain a complex machine learning failure to a non-technical stakeholder.

  • 02

    Pick an incident you personally drove, ideally one where writes were affected rather than reads. In six to eight minutes: state the symptom as it first appeared on a dashboard, the blast radius you established before you knew the cause, the mitigation you applied and when, the mechanism you eventually proved, and the follow-up that would prevent a repeat. Bring numbers: error rate, tenants affected, minutes to mitigate, minutes to resolve. If you cannot name what you measured, choose a different incident.

  • 03

    A field in a write endpoint's response must change shape. You own the endpoint; you do not own the four internal callers or the outbound webhook consumers who read it. Describe a deprecation you were responsible for: what you shipped first, how you established who was actually reading the field, the window you gave and what set its length, what you did about the consumer who never moved, and how you decided removal was safe. Name the signal you used, not the announcement you sent.

PracHub interview preparation framework ↗
Is this an official Novo Nordisk interview guide?

No. It is PracHub's own research and practice material for the Machine Learning Engineer role at Novo Nordisk. Rounds and questions reflect what candidates have reported, not a process Novo Nordisk has published, and they change over time. Confirm the current format and scope with your recruiter.

PracHub interview research ↗
Will there be a live coding or LeetCode-style interview?

While you should be prepared for basic coding questions, recent candidates report a surprising lack of traditional "gotcha" algorithms or LeetCode-style rounds. The technical evaluation heavily favors your slide presentation and deep-dive discussions into your past work.

PracHub interview research ↗
How large is the panel interview, and how should I handle it?

The panel can be quite large, sometimes featuring up to 10 interviewers. The best approach is to treat it like an academic defense or a professional conference presentation. Make eye contact, pace yourself, and be prepared for highly informed questions from various domain experts in the room.

PracHub interview research ↗
What is the culture like during the interview process?

The culture is highly professional but exceptionally respectful. Even in the event of a rejection, hiring managers have been known to call candidates personally to provide feedback and offer internal referrals to other departments. They value honesty, rigor, and mutual respect.

PracHub interview research ↗
How long should my presentation be?

You will typically be given specific guidelines by your recruiter, but aim to keep the core presentation concise (e.g., 20-30 minutes) to leave ample time for the Q&A portion, which is where the true evaluation happens.

PracHub interview research ↗
Sources & methodology 3 sources ↗

No official company page is cited. Rounds and questions come from candidate reports and PracHub editorial material; each source shows the date it was read.