A Machine Learning Engineer at Recursion Pharmaceuticals operates at the revolutionary intersection of technology and biology. The core mission of this role is to scale and productionalize machine learning models that can decode biology to radically improve lives. Unlike traditional tech companies where ML might optimize ad clicks or recommendation engines, at Recursion Pharmaceuticals, your work directly accelerates drug discovery. By analyzing massive, high-dimensional biological datasets—primarily high-throughput cellular images—you will help identify novel therapeutic candidates and map complex disease biologies.
The impact of this role is immense. Recursion Pharmaceuticals houses one of the world's largest proprietary biological datasets, which requires highly sophisticated, scalable pipelines to process. As a Machine Learning Engineer, you are responsible for building the infrastructure, MLOps frameworks, and deep learning models that turn raw imaging and genomic data into actionable biological insights. You will collaborate closely with biologists, chemists, data scientists, and software engineers to ensure models are not just theoretically sound, but robustly integrated into the company's automated discovery platform.
This position demands a unique blend of deep learning expertise, software engineering discipline, and a strong appreciation for scientific data. Candidates must be prepared to tackle highly complex data scaling challenges, design robust model training pipelines, and deploy production-grade code. It is an inspiring yet rigorous environment where engineering excellence directly translates into saving human lives.
HR Screening Call
reportedThe person on this call usually cannot evaluate your code and does not need to. They write a short paragraph, and that paragraph is what a hiring manager skims when deciding who to put on your loop. So the test is not whether your work was hard, it is whether a non-engineer can repeat it correctly. Name systems by what they did rather than by their internal codename, give each project a shape (what was breaking, what you changed, what happened after), and keep the whole walkthrough near ninety seconds. Depth that cannot survive a paraphrase reads as vagueness.
What to demonstrate
- Whether a non-engineer can restate your projects without distorting them, since their paraphrase is what travels to the hiring manager, not your sentences
- Whether each project has a shape rather than a stack list: the failure or constraint, the change you made, the result and how it was measured
- Whether you can say what was yours inside a team project without either inflating it or disappearing into the plural
How to prepare
- Rewrite each headline project as two sentences with no internal system names and no acronyms outside your company, then say them to someone outside engineering and have them repeat them back. Fix whatever came back wrong
- Attach one measured number to each project: the baseline, the change, and the window it was measured over. Where nothing was ever measured, say that plainly rather than reaching for a plausible percentage
- Time the background walkthrough against a clock. If it runs past two minutes, compress the earliest role to a single clause and spend the recovered time on the most recent one
Technical Screen
reportedWhat this round decides is narrow: whether you can produce code that runs and is correct on inputs nobody showed you. An elegant solution that does not compile scores below a plain one that does, so write a correct brute force first, say out loud that you know its cost, and improve it with the working version still on screen. What separates strong answers is who finds the broken case. Trace your own code against an empty input, a single element, and duplicate keys before you say you are finished, because being told is far more expensive than noticing.
What to demonstrate
- Whether degenerate inputs get checked without being asked for: an empty collection, one element, every element equal, and the extreme value the input type allows
- Whether the complexity you state matches the code you actually wrote, including a sort or a copy sitting inside a loop
- Whether the finished answer is verified against the worked examples before you call it done, rather than assumed correct because the code reads correctly
How to prepare
- Take five problems you have already solved and, without running anything, write down what each returns for empty input, a single element, and all-duplicates. Then run them and count how many you predicted wrong.
- Drill the brute force as its own skill: on ten problems, write only the obviously-correct slow version and time how long it takes to get it passing. If that is more than a few minutes, that is what to practise, not the optimal version.
- Add a fixed last step before you submit anything, reading only the loop bounds and the initial value of each accumulator, which is where most off-by-one errors live
Onsite Loop
reportedNobody in the room with you decides this. Interviewers typically write their rounds up separately, often before seeing anyone else's, and the outcome is settled later from those write-ups. A split panel gets resolved by whichever note carries specific evidence, so what you want out of each room is one concrete thing that person could write down: a bug you caught yourself, a trade-off you named, a decision you owned. The rest is arithmetic. The project you describe in a behavioural conversation is often the same system you sketched an hour earlier, and the two accounts have to agree.
What to demonstrate
- Whether the scale, team size and timeline you attach to a project hold steady when that project resurfaces in a different round
- Whether each interviewer leaves with a specific thing to cite rather than a general impression of competence
- Whether a trade-off you defended in one round survives a challenge in another, instead of being quietly swapped for the answer the new interviewer seemed to want
- Whether a question you have already answered earlier in the day gets the same answer at the same depth, without visible impatience
How to prepare
- Write a one-page sheet per project fixing the figures you will quote — request volume, data size, team size, elapsed time, what broke — and say them aloud from the sheet until they come out identical every time
- For each round on the schedule, decide in advance the one sentence you want in that person's notes, then check in a mock that you said it outright instead of leaving it to be inferred
- Have someone ask you the same project question twice, an hour apart, and diff the two answers for numbers that moved or a trade-off that reversed
Programming Interview
reportedWhen a round has no standard shape, it is often there because something is still open: an area no earlier conversation reached, a round where the signal came out mixed, or a decision someone is not ready to make alone. Work out which by going back over what each earlier round actually covered rather than how it felt, and arrive able to give evidence on that point without being asked twice. Weak answers replay the loop's earlier material at the same depth. Strong ones go a level deeper and stay consistent with what you already said.
What to demonstrate
- Whether your account of a project matches the one you gave earlier in the loop, since what you said before may be available to whoever runs this round
- Whether you can go a level deeper on something already covered, reaching the decision and its alternatives rather than repeating the summary
- Whether you state your own uncertainty accurately, including parts of a system you did not build and decisions you inherited, instead of claiming even ownership across all of it
- Whether you can answer a question you handled poorly earlier by naming what you missed, rather than delivering a polished second version as if the first had not happened
How to prepare
- Reconstruct the loop on one page: for each round, the questions you were asked and the answer you actually gave, not the better one you thought of afterwards. The gaps on that page are your best available guess at why this round exists.
- Take the two claims you made earlier that carry the most weight and assemble the backing for each: the measurement, the date, what broke, the decision you would make differently now.
- Write down the three facts about your work that must not drift between tellings, such as team size, timeline and your own role, and check your stories against that list rather than trusting recall under pressure
System Design Interview
reportedWhen a round has no standard shape, it is often there because something is still open: an area no earlier conversation reached, a round where the signal came out mixed, or a decision someone is not ready to make alone. Work out which by going back over what each earlier round actually covered rather than how it felt, and arrive able to give evidence on that point without being asked twice. Weak answers replay the loop's earlier material at the same depth. Strong ones go a level deeper and stay consistent with what you already said.
What to demonstrate
- Whether your account of a project matches the one you gave earlier in the loop, since what you said before may be available to whoever runs this round
- Whether you can go a level deeper on something already covered, reaching the decision and its alternatives rather than repeating the summary
- Whether you state your own uncertainty accurately, including parts of a system you did not build and decisions you inherited, instead of claiming even ownership across all of it
- Whether you can answer a question you handled poorly earlier by naming what you missed, rather than delivering a polished second version as if the first had not happened
How to prepare
- Reconstruct the loop on one page: for each round, the questions you were asked and the answer you actually gave, not the better one you thought of afterwards. The gaps on that page are your best available guess at why this round exists.
- Take the two claims you made earlier that carry the most weight and assemble the backing for each: the measurement, the date, what broke, the decision you would make differently now.
- Write down the three facts about your work that must not drift between tellings, such as team size, timeline and your own role, and check your stories against that list rather than trusting recall under pressure
Behavioral Interview
reportedWhat you say here is written down by each interviewer and compared afterwards, so the unit of evaluation is a claim someone else could check, not a well-told narrative. Two things make a story checkable: detail only a participant would hold, and a clean line around which part was yours. Vague ownership is the usual failure and it is usually accidental, because engineers say we about the team's work and we about their own, so the thing they personally built disappears into the plural. Name the part you wrote, and name who did the rest.
What to demonstrate
- Whether your details are ones a participant would hold and an observer would not: the constraint that ruled out the obvious approach, the first attempt that failed, the person who objected and on what grounds
- Whether ownership survives a direct question, since a follow-up to we decided is routinely who decided, and an answer that stays plural at that point is read as the work belonging to someone else
- Whether the numbers you quote are ones you would say identically to a former colleague with the dashboard open
How to prepare
- Go through each story replacing every we with either I or a named role (the on-call engineer, the reviewer, the other team) and check the story still holds together. Wherever it stops making sense you have found a part you cannot actually speak to
- Open the artefacts for two of your stories, the pull request, the design doc, the incident notes, and read them for dates and figures you have been rounding in the retelling. Correct your version to match
- For each story write the single sentence you would least want repeated to a former teammate, then either make it accurate or take it out
PracHub editorial advice for the preparation topics above.
Letting a slow dependency consume unbounded concurrency
The failure that takes a service down is usually not an error but a delay. A dependency answering in thirty seconds instead of fifty milliseconds holds each request's worker or connection six hundred times longer, and since required concurrency is arrival rate times latency, a fleet sized for sixty in-flight requests now needs thirty-six thousand to sustain the same rate - so it queues, and requests whose clients have already abandoned them still occupy resources. Retries make it precisely worse: a policy of three attempts triples the load on a dependency at the exact moment it is least able to serve, which is how one slow dependency becomes an outage of everything sharing that pool. Containment is four specific things - a timeout on every outbound call shorter than the caller's remaining budget, a bounded pool per dependency so one cannot starve the others, backoff with full jitter rather than a fixed delay so retries do not resynchronise, and a circuit that stops sending once the failure rate makes an attempt pointless.
Paginating with LIMIT/OFFSET over a set that changes while the client is reading it
OFFSET n makes the database produce and discard n rows before returning anything, so the cost of a page grows with its depth rather than with its size and page 500 costs five hundred pages of work. The correctness problem is worse than the cost: if a row is inserted or reordered between two page fetches, rows shift across the offset boundary and are either skipped entirely or returned twice, and neither outcome leaves any trace in the response for the client to detect. Keyset pagination - WHERE (sort_key, id) < ($last_sort_key, $last_id) ORDER BY sort_key DESC, id DESC LIMIT n, backed by an index in exactly that order - reads only the rows it returns and is stable against concurrent inserts. It requires the tie-break column: a timestamp is not unique, and duplicate sort keys straddling a page boundary reintroduce the skip it was adopted to remove.
Reading the constraints as preamble rather than as part of the problem
The bounds are usually there to eliminate the obvious approach: n up to 10^5 makes an O(n^2) scan roughly 10^10 operations, far outside any per-test time budget, and an input larger than memory rules out loading it at all. When a bound is not given, ask for it, then say out loud which approach it kills.
Never running a concrete value through the code
Trace one small input and one edge input by hand, index by index, out loud. Re-reading your own code catches design mistakes; walking a real value through it catches the off-by-one, the uninitialised accumulator and the loop that never advances.
Choose a category, try a prompt, then open its approach, worked solution or follow-up when you need it.
What strategies do you use to optimize model training speed and resour…
What strategies do you use to optimize model training speed and resource utilization when working with multi-terabyte datasets?
Approach
- State the learning problem: the label, the unit of prediction and how the model is used.
- Pick the metric from the cost of each error type, not from habit.
- Say how you would validate it, and where leakage could enter the split.
Follow-up
- How would you know the model is overfitting?
- Where could label leakage enter this setup?
Explain the mathematical formulation of backpropagation in a simple ne…
Explain the mathematical formulation of backpropagation in a simple neural network.
Approach
- State the learning problem: the label, the unit of prediction and how the model is used.
- Name the simplest model that could work and what would make you move past it.
- Pick the metric from the cost of each error type, not from habit.
Follow-up
- Where could label leakage enter this setup?
- How would you know the model is overfitting?
Work through the derivation of a convolutional layer's receptive field…
Work through the derivation of a convolutional layer's receptive field on paper.
Approach
- Name the simplest model that could work and what would make you move past it.
- Pick the metric from the cost of each error type, not from habit.
- Say how you would validate it, and where leakage could enter the split.
Follow-up
- What changes if the classes are heavily imbalanced?
- Where could label leakage enter this setup?
Write a script to find and process specific file patterns in a deeply …
Write a script to find and process specific file patterns in a deeply nested directory structure using only standard shell commands.
Approach
- Pick the metric from the cost of each error type, not from habit.
- Name the simplest model that could work and what would make you move past it.
- Say how you would validate it, and where leakage could enter the split.
Follow-up
- How would you know the model is overfitting?
- Where could label leakage enter this setup?
Merge partitioned event streams into one ordered feed with bounded lateness
The read-model service consumes 64 log partitions carrying about 4,000 events per second in total. Each partition is ordered within itself, but partitions drift by up to 30 seconds, and the activity feed must present a tenant's events in occurred_at order. Produce the merge. State its complexity, the buffer it requires in events and in bytes, what happens when one partition is idle, and what you do with an event that arrives after you have already emitted its position. Payloads average 1 KB.
Approach
- Merge with a min-heap over the 64 partition heads keyed on (occurred_at, event_id): O(log P) per event and O(n log P) overall. The tie-break on event_id is what makes the output deterministic when two partitions carry the same millisecond, which matters because the feed is paginated and a non-deterministic order reorders pages under the reader.
- Emitting the heap head is only correct once every partition has produced everything up to that timestamp, so the emit condition is a watermark: the minimum across partitions of the highest occurred_at seen, less the allowed lateness. Events are held until the watermark passes them, which is what turns individually ordered streams into a jointly ordered one.
- Size the buffer from the lateness rather than guessing: 4,000 events per second times 30 seconds is 120,000 buffered events, and at 1 KB each about 120 MB of heap. That number is the real price of the ordering guarantee and belongs in front of whoever asked for it.
- Handle the idle partition explicitly, because it fails the feed rather than corrupting it: a partition with no traffic never advances its own maximum, so the watermark freezes and output stops entirely. Either every partition emits a periodic idle marker carrying the broker's current time, or the watermark falls back to wall clock for a partition silent beyond a threshold.
- Choose the late-event policy from what the projection is keyed on. The projection upserts on (aggregate_id, aggregate_version) and discards a version it has already applied, so a late event is safe to apply out of order and correctness never depended on the merge at all. Apply it, recompute the affected feed page, and count lateness so the 30-second budget can be re-derived from data rather than folklore.
- Say what the merge does not buy: ordering is guaranteed within one aggregate by the log's partitioning, and no watermark makes the cross-aggregate order authoritative. Two events from different aggregates in the same millisecond have no true order, so the feed's order is a presentation choice that must be stable rather than correct.
Worked solution 35 min
- Write the heap comparator on (occurred_at, event_id) and the per-partition head refill.
- Write the watermark computation and the emit-loop condition, then list which buffered events are held at a chosen instant.
- Compute the buffer at 4,000 events per second, 30 seconds and 1 KB per event, and state what fraction of a worker's heap that represents.
- Add the idle-partition marker and trace the watermark with one silent partition, both with and without the marker.
- Write the late-event path and name the key that makes applying it safe.
Follow-up
- The lateness budget is raised to five minutes. What is the new buffer, and what besides memory changes?
- The consumer restarts. Where does it resume from, and what does the feed look like for the first 30 seconds?
- One partition is ten minutes behind because its producer is slow. Do you stall the feed or emit without it?
Find version gaps and relay lag with window functions
outbox_event holds event_id, aggregate_type, aggregate_id, aggregate_version, event_type, payload, status ('pending','published','dead'), attempts, created_at, published_at. A projection is missing rows and you must decide whether the relay skipped events or the consumer dropped them. Write three queries over the last seven days: one listing every aggregate_id whose published aggregate_version sequence has a hole, one giving per-day counts with a running total, and one returning the newest published event per aggregate. For each, say where the window function is evaluated relative to WHERE and LIMIT. PostgreSQL 16.
Approach
- Gaps: compute lead(aggregate_version) OVER (PARTITION BY aggregate_id ORDER BY aggregate_version) in a subquery, then filter next_version <> aggregate_version + 1 in the outer query. Window functions are evaluated after WHERE, GROUP BY and HAVING and before the outer ORDER BY and LIMIT, so the predicate cannot sit in the same WHERE clause and PostgreSQL 16 has no QUALIFY.
- Say what the seven-day filter does to the answer: it truncates every partition, so the first row per aggregate has no predecessor inside the window and a hole spanning the boundary is invisible. Widen the window, or join to resource.version as the authority for the true maximum.
- Running total: SELECT date_trunc('day', created_at) AS d, count() AS n, sum(count()) OVER (ORDER BY date_trunc('day', created_at) ROWS UNBOUNDED PRECEDING). An aggregate inside a window call is legal because grouping runs before windowing. The grouping key is unique per row here so ROWS and RANGE agree, but write the frame anyway — over ungrouped rows with tied timestamps the default RANGE frame pulls in every peer row and the total jumps.
- Newest per aggregate: DISTINCT ON (aggregate_id) ... ORDER BY aggregate_id, aggregate_version DESC is the cheap PostgreSQL-only form when an index matches that order; row_number() OVER (PARTITION BY aggregate_id ORDER BY aggregate_version DESC) = 1 is the portable form and needs a subquery for the same evaluation-order reason as the gap query.
- Interpret rather than report: no gaps plus a normal p95 of published_at - created_at points at the consumer; gaps or a fat lag tail point at the relay; rows still 'pending' with attempts > 0 point at neither, because they never left the database.
- Be explicit that the partial index on (created_at, event_id) WHERE status = 'pending' does not serve any of these — they read published rows. Name the index a recurring monitor would need, and say why a query run twice a year may not deserve one.
Follow-up
- Relay failover redelivers events. Does a duplicate break the gap query, and how would you detect one from this table alone?
- Turn the gap check into a continuous monitor rather than a query someone runs after an incident. What does it watch?
- The consumer claims it never received event 4,812,006. What do you look at, in what order?
Write the update path that detects a concurrent edit
resource carries version INT NOT NULL DEFAULT 1. resource_revision holds revision_id, resource_id, version, actor_user_id, change_kind, patch JSONB, request_id, created_at with UNIQUE (resource_id, version). outbox_event holds aggregate_type, aggregate_id, aggregate_version, event_type, payload, status. A PUT carries the version the client read. Write the exact statements for the single transaction that applies the edit, records the revision and enqueues 'resource.updated', and give the handler's branch on zero affected rows. Then say what PostgreSQL 16 does under READ COMMITTED when two of these updates hit one row at once.
Approach
- One transaction, three writes, no network call inside it: UPDATE resource SET title = $3, version = version + 1, updated_at = now() WHERE resource_id = $1 AND tenant_id = $4 AND version = $2; then INSERT the resource_revision row at version $2 + 1; then INSERT the outbox_event row at the same aggregate_version. The event goes to a table rather than a broker because no transaction spans both.
- Branch on the affected-row count before doing anything else. Zero has three causes — stale version, wrong tenant, row gone — so re-read once and map to 409 carrying the current version, or 404 for an id outside the caller's tenant, which also stops the endpoint confirming that another tenant's id exists.
- State the engine behaviour instead of assuming it. Under READ COMMITTED the second UPDATE blocks on the row lock, and when the first commits PostgreSQL re-evaluates the WHERE clause against the newly committed row, so the version predicate now fails and the statement reports zero rows. Under REPEATABLE READ the identical collision raises SQLSTATE 40001 instead, so the handler must fold both shapes into one conflict response.
- Keep UNIQUE (resource_id, version) even though the predicate already serialises writers. It is what makes a lost update unwritable if any other path ever reaches the revision table, and it converts a logic bug into 23505 rather than into a silently missing history row.
- Refuse to auto-retry the whole PUT. A retry re-reads the winner's state and reapplies an intent formed against data that no longer exists — the silent overwrite the version token was added to detect. Return the conflict; merge field-wise only if the patches are provably disjoint.
- Note that now() is the transaction timestamp in PostgreSQL, so resource.updated_at, the revision's created_at and the outbox row share one instant, which is what later makes reconciliation between the three tables unambiguous.
Worked solution 25 min
- Write the three statements plus the rowcount branch and confirm they sit in one BEGIN/COMMIT with no outbound call between them.
- Run two clients that both read version 7 and apply their updates 5 ms apart; assert one 200 and one 409.
- Assert resource.version = 8, exactly one resource_revision row at version 8, and one outbox_event row at aggregate_version 8.
- Repeat at REPEATABLE READ and record the different failure shape (SQLSTATE 40001) the handler must also map to 409.
- Delete the version predicate and re-run: both writes commit and the first edit disappears with no error raised anywhere.
Follow-up
- A client sends the version it read ten minutes ago and the resource has moved three versions. What is in your 409 so it can resolve the conflict without a full re-fetch?
- Two editors, two disjoint fields, no overlap. Does your answer still refuse the second write, and should it?
- Every write now touches a second hot table. How do you keep the outbox insert and its partial index from becoming the write bottleneck at 1.2k writes/second?
Design the bulk write endpoint a migration script retries blindly
A customer's migration script pushes 2 million resources through POST /v1/resources:batch, up to 500 items per call, and retries any call that errors or times out. Within a call some items fail validation, some collide with rows that already exist, and some succeed. Specify the request and response shape, whether a batch is atomic or per-item, how idempotency works for the call and for each item, the status code for a mixed outcome, the size and item-count limits with their error codes, and exactly what the script does after a timeout mid-batch.
Approach
- Choose atomicity deliberately and price it. All-or-nothing means one transaction holding locks for the whole batch on a primary already absorbing about 1.2k writes/second, which bounds batch size by lock duration, and it turns one bad row into 499 rejections the script must resend. Per-item partial success is the right default for a migration, and the contract's job is then to make a partial outcome impossible to miss.
- Require a client-supplied id on every item and echo it in every result. Deriving a per-item key from the array index breaks the first time the script resends a batch with the failures removed: the indices shift, previously-succeeded items acquire new keys, and they are created a second time.
- Key the effects at two levels. The call's Idempotency-Key covers an exact resend of the same bytes; per-item keys of (tenant_id, client_item_id) make a partially-applied batch safe to resend whole. Resending an identical batch must reproduce the same per-item results, not 500 conflicts the script has to interpret.
- Answer a mixed outcome with one status plus per-item detail: 200, or 207 borrowed from WebDAV if you prefer it - document whichever you pick - carrying an array of client_item_id, per-item status, and either resource_id or an error code from the same taxonomy the single-item endpoint uses. Reserve 4xx for the request as a whole: unparseable body, too many items, payload over the limit (413). Put a failed count at the top level so that even a script checking only the cheapest thing cannot conclude success while rows were dropped.
- Cap the request before doing any of it: item count, total bytes, and concurrent batches per tenant, since one tenant's migration otherwise consumes write capacity everyone shares. Anything that cannot finish inside the request deadline belongs on job_run behind a 202, not in a synchronous call that will time out halfway.
- Script behaviour after a timeout: the outcome is unknown and no results were received, so resend the identical batch with the same keys and read the results. Never resend 'only the items I have no result for' - a timeout yields no results at all, and that rule silently means resend everything anyway.
Worked solution 30 min
- Write the request schema with the per-item client id, and the response schema with per-item status and a top-level failed count.
- Write the atomicity decision and the sentence of justification that names the lock cost or the resend cost.
- Define both key levels and trace a resend of a half-applied batch through them, item by item.
- List the whole-request rejections with their status codes and limits.
- Write the script's timeout rule and the pacing it should apply between calls.
Follow-up
- At 500 items per call, what is the wall-clock time for 2 million rows, and what pacing do you publish so the migration does not become an incident?
- One item in every batch fails with the same code. How does the script discover that without a human reading logs?
Make resource creation safe for a client that retried a timeout
POST /v1/resources creates a resource row and, in the same transaction, a resource_revision and an outbox_event. A partner's HTTP client times out at 2 seconds and retries twice; under load the first request is still executing when the retry arrives, and duplicate resources are appearing. Using idempotency_key (tenant_id, idempotency_key, request_fingerprint, state, response_status, response_body, resource_id, locked_until, expires_at), specify the whole contract: first call, concurrent retry, retry after completion, a key reused with a different body, and what the client does with each response.
Approach
- Name why the plain REST shape fails here. POST is not idempotent, a timeout leaves the client unable to distinguish a lost request from a lost response, so it must retry - and the retry is a second create. Checking whether the key exists and then inserting it is check-then-act: under exactly the concurrency that caused the timeout, both attempts look, both see nothing, both proceed.
- Let the unique constraint arbitrate instead. INSERT the key row with state 'in_flight' and locked_until set to now plus the request deadline, and commit that reservation on its own before any work is attempted - an uncommitted row is invisible to the concurrent retry, which is the entire point of writing it first. One caller wins the insert and proceeds; the other takes the unique violation and reads the row rather than falling through to the work.
- Branch the loser on what it found. 'succeeded' replays response_status and response_body verbatim, with a header marking it a replay. 'in_flight' with locked_until in the future returns 409 and a Retry-After - do not park a request thread waiting on another request, that is how a concurrency bound is consumed by retries. 'in_flight' past locked_until is reclaimable by a conditional UPDATE predicated on the old locked_until, so exactly one reclaimer wins. A fingerprint mismatch is 422 and never the stored response: a different body under the same key is a client defect, and serving the old response hides it forever.
- Commit the effect and the key's completion together - resource insert, revision row, outbox row, and the UPDATE of the reserved key to 'succeeded' with the stored response, in one transaction. That makes a crash binary: either all of it is durable and the key reads 'succeeded', or the transaction rolls back and the only durable trace is the reservation row, still 'in_flight', with no resource behind it. The reclaim branch finishes that case - once locked_until passes, one retry takes the row by conditional UPDATE and runs the work for the first time. Splitting the two commits is what creates the window with no recovery: the effect durable, the key still 'in_flight', and a reclaimer that cannot distinguish that from work never started, so it creates a second resource.
- State the lifetime explicitly. Keys expire - 24 hours is a common choice - and are swept, so the client's total retry window must be shorter than the TTL, or a late retry re-executes with no record that it is a duplicate. The key is scoped by tenant so two tenants choosing the same string do not collide, and the client generates one key per logical attempt, not per network send.
- Write the client rules: on timeout, retry the same key with capped backoff; on 409, wait Retry-After and retry the same key; on 422, stop and fix the caller; on 2xx, treat the body as authoritative whether it was executed or replayed.
Follow-up
- Response bodies are pruned at 24 hours but resource_id is kept. What do you return to a replay that arrives after pruning?
- The endpoint now also sends a welcome email. Which part of this contract prevents a second send, and which part cannot?
- What exactly breaks if the key is scoped globally rather than per tenant?
Every query on one table stalls for forty seconds mid-deploy
During a release on PostgreSQL, every query touching resource times out for about 40 seconds and then recovers with no intervention. The release ran one migration, ALTER TABLE resource ADD COLUMN archived_reason TEXT, and the migration log shows it completing in 6 ms. Unrelated tables showed no change in error rate. Explain how a 6 ms statement caused a 40-second stall, give the ordered checks you would run on a live system to confirm it, and give the migration procedure that prevents a repeat.
Approach
- Separate the statement's duration from the lock's duration. ADD COLUMN with no default is a catalogue-only change and genuinely runs in milliseconds, but it requires ACCESS EXCLUSIVE, and it cannot acquire that until every transaction already touching the table has finished.
- Account for the queueing, which is the part that surprises people. A lock request that is waiting blocks later requests for conflicting modes behind it rather than letting them overtake, so one long-open transaction holds the DDL and the DDL holds all the traffic. The stall length is set by the longest open transaction, not by the size of the change.
- Confirm on a live system in this order: pg_stat_activity for that table ordered by xact_start, looking for the oldest transaction and specifically for state = idle in transaction; then pg_locks where granted = false to find the waiter; then join them on pid to name blocker and blocked. pg_blocking_pids() does that join for you and is the fastest single call.
- Prevent rather than merely time it better. Set lock_timeout to a second or two on the migration session so the DDL abandons the queue after a bounded wait and is retried, instead of holding it for as long as the oldest transaction lives. Be exact about what that buys: queries arriving during the wait still queue behind the pending ACCESS EXCLUSIVE request, so each attempt costs them up to one lock_timeout of added latency. The outage goes from 40 seconds to about one second per attempt, not to zero. Also run migrations away from deploy-time peaks, and put a statement timeout and an idle-in-transaction timeout on the analytics role that opens the long transactions.
- Know the lock each change takes, since the mitigation differs by change. A column with a non-volatile default is a metadata-only change from PostgreSQL 11 and still needs the brief ACCESS EXCLUSIVE; an index needs CREATE INDEX CONCURRENTLY, which cannot run inside a transaction block and leaves an INVALID index to drop if it fails; a check or foreign key is added NOT VALID and then VALIDATE CONSTRAINT as a separate statement under a weaker lock.
Follow-up
- The same release also wants NOT NULL on that column. What is the sequence that gets there without a long lock?
- Your lock_timeout retry fails ten times in a row because the analytics transaction is always open. What do you change?
- How does this differ on MySQL with InnoDB online DDL, and what is the equivalent of the waiting-lock queue there?
Four days sample coding, design, fundamentals and the practical rounds at deliberately shallow depth, which is enough to surface the topics you did not know were in scope. That map, rather than a guess made on day one, decides where the last three days go.
Prepare, practise & reflect
One practical outcome each day. Spend longer where you need it.
0 / 7 done01Coding, one pass at shallow depth
- Solve one problem from each of six families, an array with two pointers, hash counting, binary search, a tree traversal, a graph traversal and one dynamic program, under a hard twenty-minute cap with no extensions, marking each finished, late, or stalled.
- For every stall, write the exact move you could not make rather than the subject, so the note reads could not turn the recurrence into a loop rather than bad at dynamic programming.
- Fix nothing today. The value of the pass is the unfixed record.
Deliverable: Six timed attempts marked finished, late or stalled, each stall carrying a named blocking move.
Practice prompt ↗Practice prompt ↗Worked solution ↗02Design, one pass at shallow depth
- Spend twenty minutes each on three different shapes, a read-heavy feed, a write-heavy ingest path, and something needing a transaction across two entities, stopping each at requirements, interface and data model.
- After each, write the first question you could not answer, which is usually a number you could not estimate or a failure mode you had no vocabulary for.
- Mark which of the three you would be most relieved not to be asked, and treat that as data rather than as a preference.
Deliverable: Three shallow designs, each with the first unanswerable question written at the bottom.
Practice prompt ↗Practice prompt ↗03Fundamentals and the practical rounds
- Answer eight short questions in writing at four minutes each, covering the material that fills the gaps between the big rounds: what happens between a URL and a rendered page, what an index costs on write, when a process is preferable to a thread, and what conditions a deadlock requires.
- Do one thirty-minute practical task of the kind a take-home compresses: read an unfamiliar two-hundred-line file and write what it does, what you would change, and the one thing you remain unsure of.
- Score every answer fluent, correct but slow, or absent, and keep the absent ones visible.
Deliverable: Eight scored short answers and one written reading of unfamiliar code.
Practice prompt ↗Practice prompt ↗04The rounds that are about you, and the map
- Deliver three behavioural answers aloud against a timer, a conflict, a failure you owned, and a decision made without enough information, marking any that ran past three minutes or contained no number.
- Assemble the map: every marked item from days one to three on a single page, sorted by how likely it is to appear in your loop rather than by how uncomfortable it felt.
- Choose exactly two areas for the remaining three days and write down what you are deliberately abandoning.
Deliverable: A one-page scored map of the whole surface area with two areas chosen and the rest explicitly abandoned.
Practice prompt ↗Practice prompt ↗Worked solution ↗05First chosen area, to the depth you skipped
- Work the higher-ranked area in four focused blocks, choosing items one level above where you stalled rather than repeating what already works.
- After each block write the rule you extracted in one sentence with its precondition attached, since a rule carrying no precondition is exactly what fails under a variation.
- Re-attempt the day-one or day-two item that exposed this area and compare against the original timing.
Deliverable: Four worked blocks, a timed re-attempt against the original, and three one-sentence rules with preconditions.
Practice prompt ↗Practice prompt ↗06Second chosen area, where the gap is coverage rather than speed
- Treat the second area differently from the first. Day five drilled something you could already half-do; this one is usually a topic you had simply never met, so build one worked reference example end to end and keep it, rather than attempting six problems badly.
- Write down the vocabulary you were missing on day two or three, five terms at most, each with the one sentence that makes it usable in an answer rather than the textbook definition.
- Redo the shallow attempt that exposed this area and note whether you now fail later in the problem, because moving the failure point is the realistic gain from a single day and is worth more than a score that did not change.
Deliverable: One worked reference example for the newly covered area, a five-term vocabulary list, and a note on where the failure point moved.
Practice prompt ↗Practice prompt ↗07Reassemble the loop
- Sit two rounds back to back with no gap, ordering them so the area you chose second comes last, because the map was built from rested, isolated attempts and the loop will reach your weaker area when you are already spent.
- Write where the second round suffered from the first, which is normally the point at which structure collapses into narration.
- Reduce the week to one page holding only the rules you can state without reading them.
Deliverable: Mock notes on cross-round carryover plus a one-page card of rules you can recite from memory.
Practice prompt ↗Worked solution ↗Expand any day for tasks and deliverables. Your progress is saved on this device.
When the requirements were thin, the interesting part is how you fenced the problem off: the assumption you wrote down, who you got to confirm it, the narrow version you shipped first so the rest stayed cheap to change. Guessing and being right is luck. Guessing in writing, where someone could correct you, is method.
How do you handle data drift and model degradation over time in an aut…
How do you handle data drift and model degradation over time in an automated discovery loop?
Approach
- Give the blast radius: what could have broken, and what you measured.
- Close with what you would do differently, concretely.
- Pick a story where you made the decision, not one where you watched it.
Follow-up
- How did you know your change caused the improvement?
- What did you decide not to do, and why?
Describe your experience with model versioning, tracking, and deployme…
Describe your experience with model versioning, tracking, and deployment in a production environment.
Approach
- Name the disagreement and how you resolved it with evidence.
- State the situation in two sentences and spend the rest on the reasoning.
- Pick a story where you made the decision, not one where you watched it.
Follow-up
- How did you know your change caused the improvement?
- What would you do differently if you ran that again?
Ship under a deadline and bound the debt you chose
You have four days to ship a tenant-facing listing endpoint. The version you would defend uses keyset pagination over (tenant_id, status, updated_at DESC, resource_id DESC); the version you can finish uses LIMIT/OFFSET with no matching index. Describe a deadline call you actually made of this shape: what you shipped, what you knowingly deferred, how you bounded the damage with a mechanism rather than an intention, and the specific numeric condition that would force the follow-up. Name who you told and where you wrote it down.
Approach
- Name the deferred failure precisely instead of calling it slow. OFFSET n makes the database produce and discard n rows, so cost grows with page depth; without an index matching the sort, every matching row is read and sorted before the limit applies; and rows inserted between two page fetches shift across the boundary so items are skipped or repeated with nothing in the response to signal it.
- Bound the blast radius with something mechanical rather than a promise: cap maximum page depth, cap page size, restrict the endpoint to one internal caller, or keep it behind a flag. State which failure each cap removes and which it leaves standing.
- Attach a number to the trigger and wire it to an alarm: the first tenant crossing N resources, or the endpoint's p99 crossing its share of the 400 ms budget, so the debt announces itself instead of waiting to be remembered.
- Write it where the next engineer looks, which is the code and the ticket, not a chat message: what was deferred, why, the cap, and the trigger.
- Report what actually happened in your real example, including the case where the trigger never fired and the debt was correctly never repaid.
Follow-up
- At what page depth does the offset version breach your latency budget, given your page size and row counts?
- What breaks first when you switch to keyset pagination later, and what does a client holding an old page token see?
- Who would have overruled you if you had asked for two more days, and did you ask?
- 01
How do you handle data drift and model degradation over time in an automated discovery loop?
- 02
Describe your experience with model versioning, tracking, and deployment in a production environment.
- 03
You have four days to ship a tenant-facing listing endpoint. The version you would defend uses keyset pagination over (tenant_id, status, updated_at DESC, resource_id DESC); the version you can finish uses LIMIT/OFFSET with no matching index. Describe a deadline call you actually made of this shape: what you shipped, what you knowingly deferred, how you bounded the damage with a mechanism rather than an intention, and the specific numeric condition that would force the follow-up. Name who you told and where you wrote it down.
Is this an official Recursion Pharmaceuticals interview guide?
No. It is PracHub's own research and practice material for the Machine Learning Engineer role at Recursion Pharmaceuticals. Rounds and questions reflect what candidates have reported, not a process Recursion Pharmaceuticals has published, and they change over time. Confirm the current format and scope with your recruiter.
PracHub interview research ↗How much biology knowledge do I need to land this role?
You do not need a formal degree in biology or chemistry to succeed. Recursion Pharmaceuticals values your core engineering and machine learning expertise first. However, you must demonstrate a strong curiosity and willingness to learn biological concepts, as you will be collaborating daily with scientific teams and working directly with biological datasets.
PracHub interview research ↗Why does Recursion place such a strong emphasis on TensorFlow Extended (TFX)?
Recursion operates an industrial-scale drug discovery platform that relies on automated, reproducible, and continuous machine learning pipelines. TensorFlow Extended (TFX) and similar production-grade MLOps frameworks are critical for managing the lifecycle of these models at scale. Showing familiarity with these tools demonstrates you can build production-grade systems, not just research prototypes.
PracHub interview research ↗What is the balance between research and engineering in this role?
This is primarily an engineering role. While you will work closely with research scientists and need a deep theoretical understanding of ML models, your main responsibility is to build, scale, and productionalize these models. If you prefer pure model training and paper writing, this role may feel heavily weighted toward software engineering and systems design.
PracHub interview research ↗What is the typical timeline from the first screen to an offer?
The interview process generally takes between 3 to 5 weeks. The recruitment team is highly responsive and professional, and they typically provide feedback within a week of completing each stage of the process.
PracHub interview research ↗Sources & methodology 3 sources ↗
No official company page is cited. Rounds and questions come from candidate reports and PracHub editorial material; each source shows the date it was read.
- 01PracHub interview research ↗
PracHub editorial research into this company and role, maintained with this guide. Candidate-reported, not an employer publication.
PracHub page · Accessed 2026-09-30 - 02PracHub Machine Learning Engineer practice ↗
Cross-company practice questions for this role.
PracHub page · Accessed 2026-09-30 - 03PracHub interview preparation framework ↗
The framework the preparation plan follows.
PracHub page · Accessed 2026-09-30
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